TY - JOUR
T1 - β-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients
AU - Spinazzola, F.
AU - Barletta, C.
AU - Demartino, G.
AU - Martini, F.
AU - Natili, S.
AU - Noto, P.
AU - Ferri, F.
AU - Tossini, G.
AU - Visco, G.
PY - 1995
Y1 - 1995
N2 - Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between β-endorphin (β-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the β-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+ T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.
AB - Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between β-endorphin (β-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the β-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+ T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.
KW - β-endorphin
KW - endogenous opioid peptides system
KW - HIV infection
KW - hypothalamic-pituitary-adrenocorticosurrenalic axis
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M3 - Article
C2 - 8766783
AN - SCOPUS:0029555030
SN - 1128-3602
VL - 17
SP - 161
EP - 165
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
IS - 5
ER -