α7 nAChR in airway respiratory epithelial cells

Candida Nastrucci; Patrizia Russo

α7 nAChR in airway respiratory epithelial cells

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

This review examines the role of α7 nAChR in different types of airway epithelial cells of the normal human bronchial tree. In each of these cells α7 nAChR activation elicits a specific effect. The effect is essentially mitogenic, whereas in the airway basal cells are antiproliferative. It is postulated that α7 nAChR may have mitogenic or antiproliferative signals differentially activated in different types of airway cells and under exposure to exogenous stimuli such as nicotine.

Original language	English
Pages (from-to)	666-670
Number of pages	5
Journal	Current Drug Targets
Volume	13
Issue number	5
Publication status	Published - May 2012

Keywords

α7 nAChr
Basal cells
HBEC
HSAEC
Lung disease
Lung function
Neuroendocrine cell
Nicotine

ASJC Scopus subject areas

Drug Discovery
Pharmacology
Clinical Biochemistry
Molecular Medicine

Cite this

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AB - This review examines the role of α7 nAChR in different types of airway epithelial cells of the normal human bronchial tree. In each of these cells α7 nAChR activation elicits a specific effect. The effect is essentially mitogenic, whereas in the airway basal cells are antiproliferative. It is postulated that α7 nAChR may have mitogenic or antiproliferative signals differentially activated in different types of airway cells and under exposure to exogenous stimuli such as nicotine.

KW - α7 nAChr

KW - Basal cells

KW - HBEC

KW - HSAEC

KW - Lung disease

KW - Lung function

KW - Neuroendocrine cell

KW - Nicotine

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α7 nAChR in airway respiratory epithelial cells

Abstract

Keywords

ASJC Scopus subject areas

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