When ubiquitin meets ubiquitin receptors: A signalling connection

Pier Paolo Di Fiore; Simona Polo; Kay Hofmann

doi:10.1038/nrm1124

When ubiquitin meets ubiquitin receptors: A signalling connection

Pier Paolo Di Fiore, Simona Polo, Kay Hofmann

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.

Original language	English
Pages (from-to)	491-497
Number of pages	7
Journal	Nature Reviews Molecular Cell Biology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/nrm1124
Publication status	Published - Jun 1 2003

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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10.1038/nrm1124

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When ubiquitin meets ubiquitin receptors: A signalling connection

Abstract

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