When Sirtuins and NF-κB Collide

Gioacchino Natoli

doi:10.1016/j.cell.2008.12.034

When Sirtuins and NF-κB Collide

Gioacchino Natoli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Both the sirtuins and certain transcription factors of the NF-κB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-κB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.

Original language	English
Pages (from-to)	19-21
Number of pages	3
Journal	Cell
Volume	136
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2008.12.034
Publication status	Published - Jan 9 2009

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2008.12.034

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When Sirtuins and NF-κB Collide

Abstract

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