TY - JOUR
T1 - What is the role of postoperative re-irradiation in recurrent and second primary squamous cell cancer of head and neck? A literature review according to PICO criteria
AU - Merlotti, Anna
AU - Mazzola, Rosario
AU - Alterio, Daniela
AU - Alongi, Filippo
AU - Bacigalupo, Almalina
AU - Bonomo, Pierluigi
AU - Maddalo, Marta
AU - Russi, Elvio Grazioso
AU - Orlandi, Ester
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Re-irradiation has been increasingly offered as a potential effective treatment for head and neck squamous cell carcinoma (HNSCC) loco-regional recurrence as well as second primary tumor in previously irradiated area. This review focused on the role of postoperative re-irradiation (POreRT) in terms of feasibility, toxicity and long-term outcomes in HNSCC patients. The key issue for the research was formulated in two questions according to the PICO (population, intervention, control, and outcomes) criteria. A total of 16 publications met the inclusion criteria for a total of 919 patients; in 522 patients POreRT was performed. POreRT in recurrent and second primary HNSCC seems to be feasible in highly selected patients with the intent to guarantee an acceptable LC compared to surgery alone. The optimal RT schedule remains unclear due to the heterogeneity of literature data.
AB - Re-irradiation has been increasingly offered as a potential effective treatment for head and neck squamous cell carcinoma (HNSCC) loco-regional recurrence as well as second primary tumor in previously irradiated area. This review focused on the role of postoperative re-irradiation (POreRT) in terms of feasibility, toxicity and long-term outcomes in HNSCC patients. The key issue for the research was formulated in two questions according to the PICO (population, intervention, control, and outcomes) criteria. A total of 16 publications met the inclusion criteria for a total of 919 patients; in 522 patients POreRT was performed. POreRT in recurrent and second primary HNSCC seems to be feasible in highly selected patients with the intent to guarantee an acceptable LC compared to surgery alone. The optimal RT schedule remains unclear due to the heterogeneity of literature data.
KW - Head and neck squamous cell cancer
KW - Radiotherapy
KW - Re-irradiation
KW - Recurrence
KW - Retreatment
KW - Squamous cell carcinoma
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UR - http://www.scopus.com/inward/citedby.url?scp=85014101203&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2017.01.008
DO - 10.1016/j.critrevonc.2017.01.008
M3 - Review article
C2 - 28259292
AN - SCOPUS:85014101203
SN - 1040-8428
VL - 111
SP - 20
EP - 30
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
ER -