TY - JOUR
T1 - What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia?
AU - Altamura, C.
AU - Squitti, R.
AU - Pasqualetti, P.
AU - Tibuzzi, F.
AU - Silvestrini, M.
AU - Ventriglia, M. C.
AU - Cassetta, E.
AU - Rossini, P. M.
AU - Vernieri, F.
PY - 2007/6
Y1 - 2007/6
N2 - Evidence suggests the important role of vascular factors both in vascular dementia (VaD) and Alzheimer disease (AD) pathogenesis. However, the relationship between apolipoprotein E (APOE) polymorphism and markers of atherosclerosis is still controversial. The aim of the study was to investigate the interplay between APOE polymorphisms and atherosclerosis in patients with AD and VaD. In this cross-sectional study, 101 demented (68 AD and 33 VaD) patients underwent APOE genotyping and neck vessel ultrasound to evaluate carotid artery disease [intima-media thickness (IMT) and plaques]. Patients with AD carrying ε4 allele presented increased IMT values with respect to non-ε4 carriers and VaD patients, whereas no relation was found between APOE polymorphisms and the presence or grade of carotid plaques both in AD and VaD patients. The ε4 APOE allele may promote intima-media thickening, interacting with other factors contributing to AD development.
AB - Evidence suggests the important role of vascular factors both in vascular dementia (VaD) and Alzheimer disease (AD) pathogenesis. However, the relationship between apolipoprotein E (APOE) polymorphism and markers of atherosclerosis is still controversial. The aim of the study was to investigate the interplay between APOE polymorphisms and atherosclerosis in patients with AD and VaD. In this cross-sectional study, 101 demented (68 AD and 33 VaD) patients underwent APOE genotyping and neck vessel ultrasound to evaluate carotid artery disease [intima-media thickness (IMT) and plaques]. Patients with AD carrying ε4 allele presented increased IMT values with respect to non-ε4 carriers and VaD patients, whereas no relation was found between APOE polymorphisms and the presence or grade of carotid plaques both in AD and VaD patients. The ε4 APOE allele may promote intima-media thickening, interacting with other factors contributing to AD development.
KW - Alzheimer dementia
KW - Apolipoprotein E polymorphism
KW - Carotid atherosclerosis
KW - intimamedia thickness
KW - Vascular dementia
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U2 - 10.1111/j.1468-1331.2007.01714.x
DO - 10.1111/j.1468-1331.2007.01714.x
M3 - Article
C2 - 17539949
AN - SCOPUS:34249822830
SN - 1351-5101
VL - 14
SP - 679
EP - 682
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 6
ER -