What is the best therapy for Whipple's disease? Our point of view

F. Biagi, G. L. Biagi, G. R. Corazza

Research output: Contribution to journalArticlepeer-review


Although Whipple's disease (WD) has been treated with antibiotics since the early 50s, the best antibiotics and the duration of the therapy have not yet been established. We consider here the pro and cons of the two most commonly used therapies, ceftriaxone followed by trimethoprim-sulfamethoxazole (TMP-SMZ) and hydroxychloroquine in combination with doxycycline. The therapy based on ceftriaxone and TMP-SMZ is efficient in the vast majority of patients for the first few years. However, since reinfections or reactivations can occur, a life-long prophylaxis is necessary and doxycycline is nowadays the best option. We thus propose a therapy based on merging these to therapies together, ceftriaxone, and TMP-SMZ for the first year(s) and then life-long prophylaxis with doxycycline.
Original languageEnglish
Pages (from-to)465-466
Number of pages2
JournalScandinavian Journal of Gastroenterology
Issue number4
Publication statusPublished - Apr 1 2017


  • Anti-Bacterial Agents/therapeutic use
  • Ceftriaxone/therapeutic use
  • Doxycycline/therapeutic use
  • Drug Therapy, Combination
  • Feces/microbiology
  • Humans
  • Randomized Controlled Trials as Topic
  • Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
  • Tropheryma/drug effects
  • Whipple Disease/drug therapy
  • Ceftriaxone
  • Whipple's disease
  • doxycycline
  • trimethoprim-sulfamethoxazole
  • Tropheryma whipplei


Dive into the research topics of 'What is the best therapy for Whipple's disease? Our point of view'. Together they form a unique fingerprint.

Cite this