Wernicke encephalopathy in pediatric neuro-oncology: Presentation of 2 cases and review of literature

Maria Giuseppina Cefalo, Maria Antonietta De Ioris, Antonella Cacchione, Daniela Longo, Susanna Staccioli, Francesco Arcioni, Bruno Bernardi, Angela Mastronuzzi

Research output: Contribution to journalArticlepeer-review


Wernicke encephalopathy represents a well-known entity characterized by a set of cognitive and neurologic alterations. Wernicke encephalopathy is rare and under-recognized in childhood and may be fatal. Few cases have been documented in pediatric oncology. We report on 2 Wernicke encephalopathy cases that occurred in children having a brain tumor. The diagnosis of Wernicke encephalopathy was suggested by clinical manifestations associated with the typical radiologic findings and a laboratory evidence of thiamine deficiency. No large series have been published to support the evidence that pediatric malignancies represent a demonstrated factor of increased risk to develop a Wernicke encephalopathy. Moreover, the diagnosis may be even more difficult in brain tumors, considering the overlapping symptoms and the risk of encephalopathy related to both the disease and the treatment. Wernicke encephalopathy should be considered in all childrenwith cancer presenting a neurologic deterioration, mainly in brain tumors. An early diagnosis is imperative for a prompt therapy that might prevent or minimize the irreversible brain damage related to this condition.

Original languageEnglish
Pages (from-to)NP181-NP185
JournalJournal of Child Neurology
Issue number12
Publication statusPublished - 2014


  • Brain cancer
  • Childhood
  • Wernicke encephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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