Volatile Agents in Medical and Surgical Intensive Care Units: A Meta-Analysis of Randomized Clinical Trials

Giovanni Landoni, Laura Pasin, Luca Cabrini, Anna Mara Scandroglio, Martina Baiardo Redaelli, Carmine Domenico Votta, Mattia Bellandi, Giovanni Borghi, Alberto Zangrillo

Research output: Contribution to journalArticlepeer-review


Objective To comprehensively assess published randomized peer-reviewed studies related to volatile agents used for sedation in intensive care unit (ICU) settings, with the hypothesis that volatile agents could reduce time to extubation in adult patients. Design Systematic review and meta-analysis of randomized trials. Setting Intensive care units. Participants Critically ill patients. Interventions None. Measurements and Main Results The BioMedCentral, PubMed, Embase, and Cochrane Central Register databases of clinical trials were searched systematically for studies on volatile agents used in the ICU setting. Articles were assessed by trained investigators, and divergences were resolved by consensus. Inclusion criteria included random allocation to treatment (volatile agents versus any intravenous comparator, with no restriction on dose or time of administration) in patients requiring mechanical ventilation in the ICU. Twelve studies with 934 patients were included in the meta-analysis. The use of halogenated agents reduced the time to extubation (standardized mean difference = –0.78 [–1.01 to –0.55] hours; p for effect
Original languageEnglish
Pages (from-to)1005 - 1014
Number of pages10
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number4
Publication statusPublished - Aug 1 2016


  • anesthesia
  • critically ill
  • intensive care
  • mechanical ventilation
  • sedation
  • volatile agents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Volatile Agents in Medical and Surgical Intensive Care Units: A Meta-Analysis of Randomized Clinical Trials'. Together they form a unique fingerprint.

Cite this