TY - JOUR
T1 - Volatile Agents in Medical and Surgical Intensive Care Units: A Meta-Analysis of Randomized Clinical Trials
AU - Landoni, Giovanni
AU - Pasin, Laura
AU - Cabrini, Luca
AU - Scandroglio, Anna Mara
AU - Baiardo Redaelli, Martina
AU - Votta, Carmine Domenico
AU - Bellandi, Mattia
AU - Borghi, Giovanni
AU - Zangrillo, Alberto
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective To comprehensively assess published randomized peer-reviewed studies related to volatile agents used for sedation in intensive care unit (ICU) settings, with the hypothesis that volatile agents could reduce time to extubation in adult patients. Design Systematic review and meta-analysis of randomized trials. Setting Intensive care units. Participants Critically ill patients. Interventions None. Measurements and Main Results The BioMedCentral, PubMed, Embase, and Cochrane Central Register databases of clinical trials were searched systematically for studies on volatile agents used in the ICU setting. Articles were assessed by trained investigators, and divergences were resolved by consensus. Inclusion criteria included random allocation to treatment (volatile agents versus any intravenous comparator, with no restriction on dose or time of administration) in patients requiring mechanical ventilation in the ICU. Twelve studies with 934 patients were included in the meta-analysis. The use of halogenated agents reduced the time to extubation (standardized mean difference = –0.78 [–1.01 to –0.55] hours; p for effect
AB - Objective To comprehensively assess published randomized peer-reviewed studies related to volatile agents used for sedation in intensive care unit (ICU) settings, with the hypothesis that volatile agents could reduce time to extubation in adult patients. Design Systematic review and meta-analysis of randomized trials. Setting Intensive care units. Participants Critically ill patients. Interventions None. Measurements and Main Results The BioMedCentral, PubMed, Embase, and Cochrane Central Register databases of clinical trials were searched systematically for studies on volatile agents used in the ICU setting. Articles were assessed by trained investigators, and divergences were resolved by consensus. Inclusion criteria included random allocation to treatment (volatile agents versus any intravenous comparator, with no restriction on dose or time of administration) in patients requiring mechanical ventilation in the ICU. Twelve studies with 934 patients were included in the meta-analysis. The use of halogenated agents reduced the time to extubation (standardized mean difference = –0.78 [–1.01 to –0.55] hours; p for effect
KW - anesthesia
KW - critically ill
KW - intensive care
KW - mechanical ventilation
KW - sedation
KW - volatile agents
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U2 - 10.1053/j.jvca.2016.02.021
DO - 10.1053/j.jvca.2016.02.021
M3 - Article
SN - 1053-0770
VL - 30
SP - 1005
EP - 1014
JO - Journal of Cardiothoracic and Vascular Anesthesia
JF - Journal of Cardiothoracic and Vascular Anesthesia
IS - 4
ER -