Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population

Valentina Caputo; Marcello Niceta; Santi Fiorella; Marco La Vecchia; Emanuela Bastonini; Maria R Bongiorno; Giuseppe Pistone

doi:10.23736/S0392-0488.17.05488-8

Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population

Valentina Caputo, Marcello Niceta, Santi Fiorella, Marco La Vecchia, Emanuela Bastonini, Maria R Bongiorno, Giuseppe Pistone

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in vitiligo patients. Catalase is a well-known oxidative stress regulator that could play an important role in the pathogenesis of vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with vitiligo susceptibility in Sicilian population.

METHODS: Sixty out of 73 Sicilian patients with vitiligo were enrolled and submitted to CAT gene analysis.

RESULTS: Contrary to the Northern part of Europe but likewise to the Mediterranean area, the frequency of the CAT genotypes in Sicily is equally distributed. Out of all CAT genotypes, only CAT-89 T/T frequency was found to be significantly higher amongst vitiligo patients than controls.

CONCLUSIONS: Despite the involvement of the CAT enzyme in the pathogenesis of vitiligo, the biological significance of CAT gene polymorphisms is still controversial. With the only exception for CAT variant -89A/T, the other studied CAT gene polymorphisms (389C/T and 419C/T) might not to be associated with vitiligo in Sicilian population.

Original language	English
Pages (from-to)	619-623
Number of pages	5
Journal	Giornale Italiano di Dermatologia e Venereologia
Volume	153
Issue number	5
DOIs	https://doi.org/10.23736/S0392-0488.17.05488-8
Publication status	Published - Oct 2018

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@article{7ad81af451484aaaa2474ecf4c2433a2,

title = "Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population",

abstract = "BACKGROUND: Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in vitiligo patients. Catalase is a well-known oxidative stress regulator that could play an important role in the pathogenesis of vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with vitiligo susceptibility in Sicilian population.METHODS: Sixty out of 73 Sicilian patients with vitiligo were enrolled and submitted to CAT gene analysis.RESULTS: Contrary to the Northern part of Europe but likewise to the Mediterranean area, the frequency of the CAT genotypes in Sicily is equally distributed. Out of all CAT genotypes, only CAT-89 T/T frequency was found to be significantly higher amongst vitiligo patients than controls.CONCLUSIONS: Despite the involvement of the CAT enzyme in the pathogenesis of vitiligo, the biological significance of CAT gene polymorphisms is still controversial. With the only exception for CAT variant -89A/T, the other studied CAT gene polymorphisms (389C/T and 419C/T) might not to be associated with vitiligo in Sicilian population.",

author = "Valentina Caputo and Marcello Niceta and Santi Fiorella and {La Vecchia}, Marco and Emanuela Bastonini and Bongiorno, {Maria R} and Giuseppe Pistone",

year = "2018",

month = oct,

doi = "10.23736/S0392-0488.17.05488-8",

language = "English",

volume = "153",

pages = "619--623",

journal = "Giornale Italiano di Dermatologia e Venereologia",

issn = "0392-0488",

publisher = "Edizioni Minerva Medica S.p.A.",

number = "5",

}

TY - JOUR

T1 - Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population

AU - Caputo, Valentina

AU - Niceta, Marcello

AU - Fiorella, Santi

AU - La Vecchia, Marco

AU - Bastonini, Emanuela

AU - Bongiorno, Maria R

AU - Pistone, Giuseppe

PY - 2018/10

Y1 - 2018/10

N2 - BACKGROUND: Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in vitiligo patients. Catalase is a well-known oxidative stress regulator that could play an important role in the pathogenesis of vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with vitiligo susceptibility in Sicilian population.METHODS: Sixty out of 73 Sicilian patients with vitiligo were enrolled and submitted to CAT gene analysis.RESULTS: Contrary to the Northern part of Europe but likewise to the Mediterranean area, the frequency of the CAT genotypes in Sicily is equally distributed. Out of all CAT genotypes, only CAT-89 T/T frequency was found to be significantly higher amongst vitiligo patients than controls.CONCLUSIONS: Despite the involvement of the CAT enzyme in the pathogenesis of vitiligo, the biological significance of CAT gene polymorphisms is still controversial. With the only exception for CAT variant -89A/T, the other studied CAT gene polymorphisms (389C/T and 419C/T) might not to be associated with vitiligo in Sicilian population.

AB - BACKGROUND: Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in vitiligo patients. Catalase is a well-known oxidative stress regulator that could play an important role in the pathogenesis of vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with vitiligo susceptibility in Sicilian population.METHODS: Sixty out of 73 Sicilian patients with vitiligo were enrolled and submitted to CAT gene analysis.RESULTS: Contrary to the Northern part of Europe but likewise to the Mediterranean area, the frequency of the CAT genotypes in Sicily is equally distributed. Out of all CAT genotypes, only CAT-89 T/T frequency was found to be significantly higher amongst vitiligo patients than controls.CONCLUSIONS: Despite the involvement of the CAT enzyme in the pathogenesis of vitiligo, the biological significance of CAT gene polymorphisms is still controversial. With the only exception for CAT variant -89A/T, the other studied CAT gene polymorphisms (389C/T and 419C/T) might not to be associated with vitiligo in Sicilian population.

U2 - 10.23736/S0392-0488.17.05488-8

DO - 10.23736/S0392-0488.17.05488-8

M3 - Article

C2 - 28206724

SN - 0392-0488

VL - 153

SP - 619

EP - 623

JO - Giornale Italiano di Dermatologia e Venereologia

JF - Giornale Italiano di Dermatologia e Venereologia

IS - 5

ER -

Vitiligo susceptibility and catalase gene polymorphisms in Sicilian population

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