Vitamin K in chronic kidney disease

Mario Cozzolino, Michela Mangano, Andrea Galassi, Paola Ciceri, Piergiorgio Messa, Sagar Nigwekar

Research output: Contribution to journalReview articlepeer-review


Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification.

Original languageEnglish
Article number168
Issue number1
Publication statusPublished - Jan 1 2019


  • CKD
  • Vascular calcification
  • Vitamin K

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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