Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence

Laura Buggio, Elena Roncella, Edgardo Somigliana, Paolo Vercellini

Research output: Contribution to journalArticlepeer-review


Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, because vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids and polycystic ovary syndrome.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalGynecological Endocrinology
Issue number4
Publication statusPublished - 2016


  • Endometriosis
  • overdiagnosis
  • polycystic ovary syndrome
  • uterine fibroids
  • vitamin D

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology


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