TY - JOUR
T1 - VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas
AU - Oliva, Daniela
AU - Nicosia, Simonetta
AU - Spada, Anna
AU - Giannattasio, Giuliana
PY - 1982/9/10
Y1 - 1982/9/10
N2 - The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.
AB - The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3×10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.
KW - ACTH
KW - Adenylate cyclase
KW - Pituitary adenomas
KW - Vasoactive intestinal polypeptide
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U2 - 10.1016/0014-2999(82)90291-6
DO - 10.1016/0014-2999(82)90291-6
M3 - Article
C2 - 6290240
AN - SCOPUS:0019945132
SN - 0014-2999
VL - 83
SP - 101
EP - 105
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -