TY - JOUR
T1 - Video-assisted thoracoscopic extended thymectomy and extended transsternal thymectomy (T-3b) in non-thymomatous myasthenia gravis patients
T2 - Remission after 6 years of follow-up
AU - Mantegazza, Renato
AU - Baggi, Fulvio
AU - Bernasconi, Pia
AU - Antozzi, Carlo
AU - Confalonieri, Paolo
AU - Novellino, Lorenzo
AU - Spinelli, Luisella
AU - Ferrò, Maria Teresa
AU - Beghi, Ettore
AU - Cornelio, Ferdinando
PY - 2003/8/15
Y1 - 2003/8/15
N2 - The aims of this study were to assess the efficacy of video-assisted thoracoscopic extended thymectomy (VATET) as a treatment for myasthenia gravis (MG) and to identify prognostic factors for thymectomy success. Clinical efficacy and variables influencing outcome were assessed by life-table and Cox proportional hazards regression analysis. Complete stable remission (CSR), as defined by the MGFA Medical Task Force, was the end point for efficacy. VATET was performed in 159 MG patients and T-3b in 47 MG patients. At 6 years of follow-up, CSR, assessed by life-table analysis, was 50.6% in non-thymomatous VATET patients and 48.7% in non-thymomatous T-3b surgery. By univariate analysis, the presence of thymic hyperplasia (P=0.0002) and treatment only with anticholinesterases (P
AB - The aims of this study were to assess the efficacy of video-assisted thoracoscopic extended thymectomy (VATET) as a treatment for myasthenia gravis (MG) and to identify prognostic factors for thymectomy success. Clinical efficacy and variables influencing outcome were assessed by life-table and Cox proportional hazards regression analysis. Complete stable remission (CSR), as defined by the MGFA Medical Task Force, was the end point for efficacy. VATET was performed in 159 MG patients and T-3b in 47 MG patients. At 6 years of follow-up, CSR, assessed by life-table analysis, was 50.6% in non-thymomatous VATET patients and 48.7% in non-thymomatous T-3b surgery. By univariate analysis, the presence of thymic hyperplasia (P=0.0002) and treatment only with anticholinesterases (P
KW - Epidemiology
KW - Myasthenia gravis
KW - Predictive factors
KW - Thymectomy
KW - Thymus
KW - Video-assisted thoracoscopic extended thymectomy (VATET)
UR - http://www.scopus.com/inward/record.url?scp=20244384530&partnerID=8YFLogxK
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U2 - 10.1016/S0022-510X(03)00087-X
DO - 10.1016/S0022-510X(03)00087-X
M3 - Article
C2 - 12809996
AN - SCOPUS:20244384530
SN - 0022-510X
VL - 212
SP - 31
EP - 36
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -