Vav1 is a component of transcriptionally active complexes

Martin Houlard, Ramachandran Arudchandran, Fabienne Regnier-Ricard, Antonia Germani, Sylvie Gisselbrecht, Ulrich Blank, Juan Rivera, Nadine Varin-Blank

Research output: Contribution to journalArticlepeer-review


The importance of the hematopoietic protooncogene Vav1 in immune cell function is widely recognized, although its regulatory mechanisms are not completely understood. Here, we examined whether Vav1 has a nuclear function, as past studies have reported its nuclear localization. Our findings provide a definitive demonstration of Vav1 nuclear localization in a receptor stimulation-dependent manner and reveal a critical role for the COOH-terminal Src homology 3 (SH3) domain and a nuclear localization sequence within the pleckstrin homology domain. Analysis of DNA-bound transcription factor complexes revealed nuclear Vav1 as an integral component of transcriptionally active nuclear factor of activated T cells (NFAT)- and nuclear factor (NF)KB-like complexes, and the COOH-terminal SH3 domain as being critical in their formation. Thus, we describe a novel nuclear role for Vav1 as a component and facilitator of NFAT and NFKB-like transcriptional activity.

Original languageEnglish
Pages (from-to)1115-1127
Number of pages13
JournalJournal of Experimental Medicine
Issue number9
Publication statusPublished - May 6 2002


  • Calcium influx
  • Nuclear factor of activated T cells
  • Nuclear translocation
  • Protein subdomains
  • Vav

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Vav1 is a component of transcriptionally active complexes'. Together they form a unique fingerprint.

Cite this