TY - JOUR
T1 - Vasopressin levels in Cushing's disease
T2 - Inferior petrosal sinus assay, response to corticotrophin-releasing hormone and comparison with patients without Cushing's disease
AU - Colao, Annamaria
AU - Ferone, Diego
AU - Di Sarno, Antonella
AU - Tripodi, Francesca S.
AU - Cerbone, Gaetana
AU - Marzullo, Paolo
AU - Boudouresque, Françoise
AU - Oliver, Charles
AU - Merola, Bartolomeo
AU - Lombardi, Gaetano
PY - 1996
Y1 - 1996
N2 - Background: Higher vasopressin (AVP) levels have been found in the inferior petrosal sinus ipsilateral to the ACTH-secreting adenoma than in the contralateral one, suggesting a potential pathogenetic role of AVP in Cushing's disease. Design: In order to investigate AVP release, plasma ACTH and AVP concentrations were assayed in the inferior petrosal sinuses and in the peripheral blood before and after CRH stimulation. Patients: Twenty patients with Cushings disease and 12 with other pituitary diseases were subjected to simultaneous and bilateral inferior petrosal sinus sampling for diagnostic purposes. Ten healthy sex and age-matched subjects served as control for peripheral AVP values. Measurements: Plasma ACTH concentrations were measured by RIA using commercial kits. Plasma AVP concentrations were assayed by RIA in acetone extracts of 1-2 ml plasma. Results: Plasma AVP levels in the inferior petrosal sinuses were significantly higher in Cushing's disease than in patients with other pituitary diseases (P
AB - Background: Higher vasopressin (AVP) levels have been found in the inferior petrosal sinus ipsilateral to the ACTH-secreting adenoma than in the contralateral one, suggesting a potential pathogenetic role of AVP in Cushing's disease. Design: In order to investigate AVP release, plasma ACTH and AVP concentrations were assayed in the inferior petrosal sinuses and in the peripheral blood before and after CRH stimulation. Patients: Twenty patients with Cushings disease and 12 with other pituitary diseases were subjected to simultaneous and bilateral inferior petrosal sinus sampling for diagnostic purposes. Ten healthy sex and age-matched subjects served as control for peripheral AVP values. Measurements: Plasma ACTH concentrations were measured by RIA using commercial kits. Plasma AVP concentrations were assayed by RIA in acetone extracts of 1-2 ml plasma. Results: Plasma AVP levels in the inferior petrosal sinuses were significantly higher in Cushing's disease than in patients with other pituitary diseases (P
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M3 - Article
C2 - 8881447
AN - SCOPUS:9444253458
SN - 0300-0664
VL - 45
SP - 157
EP - 166
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 2
ER -