Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases

Carla Regina, Emanuele Panatta, Eleonora Candi, Gerry Melino, Ivano Amelio, Carmela Rita Balistreri, Margherita Maria Annicchiarico Petruzzelli, Nicola Di Daniele, Giovanni Ruvolo

Research output: Contribution to journalReview articlepeer-review


Ageing leads to a progressive deterioration of structure and function of all organs over the time. During this process endothelial cells undergo senescence and manifest significant changes in their properties, resulting in impairment of the vascular functionality and neo-angiogenic capability. This ageing-dependent impairment of endothelial functions is considered a key factor contributing to vascular dysfunctions, which is responsible of several age-related diseases of the vascular system and other organs. Several mechanisms have been described to control ageing-related endothelial cell senescence including microRNAs, mitochondrial dysfunction and micro environmental stressors, such as hypoxia. In this review, we attempt to summarize the recent literature in the field, discussing the major mechanisms involved in endothelial cell senescence. We also underline key molecular aspects of ageing-associated vascular dysfunction in the attempt to highlight potential innovative therapeutic targets to delay the onset of age-related diseases.

Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalMechanisms of Ageing and Development
Publication statusPublished - Oct 1 2016


  • Endotheliocyte
  • Endothelium
  • Hypoxia
  • microRNAs
  • Mitochondrial dysfunction
  • Oxidative stress
  • p53 family
  • p73
  • Transglutaminase 2
  • VEGF

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology


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