Variation of B-type natriuretic peptide concentrations and intrauterine growth restriction: Mother, fetus and newborn

Francesca Garofoli; S. Mannarino; L. Montanari; R. Cerbo; C. Tzialla; I. Mazzucchelli; M. Angelini; A. C. Codazzi; M. E. Mongini; P. Manzoni; C. Tinelli; A. Spinillo; M. Stronati

Variation of B-type natriuretic peptide concentrations and intrauterine growth restriction: Mother, fetus and newborn

Francesca Garofoli, S. Mannarino, L. Montanari, R. Cerbo, C. Tzialla, I. Mazzucchelli, M. Angelini, A. C. Codazzi, M. E. Mongini, P. Manzoni, C. Tinelli, A. Spinillo, M. Stronati

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

To evaluate maternal, fetal, neonatal B-type natriuretic peptide (BNP) concentrations related to Intra Uterine Growth Restriction (IUGR). BNP concentrations in 43 IUGR and 35 healthy, Appropriate for Gestational Age (AGA) infants/paired mothers have been compared, from delivery/birth to first month of life. Maternal and IUGR cord BNP concentrations were coupled to fetal ultrasonography. Neonatal echocardiography was performed too. On delivery BNP was higher in all IUGR mothers, suffering or not from gestational hypertension, than in AGA (median 37.14 vs 11.1 pg/ml p=0.002). Maternal BNP was not associated to cord/neonatal BNP or fetal ultrasonographic parameters. Cord BNP was higher in IUGR than AGA newborns (median 23.9 vs 11.4 pg/ml p=0.0007) independently of gestational age, while varied with amniotic fluid (p=0.0044) and umbilical artery flowmetry (p=0.0121). Earlier drop of BNP on day 3 was reported in IUGR neonates (p=0.0001). Ventricular mass change/body weight varied positively in AGA newborns (p

Original language	English
Pages (from-to)	733-739
Number of pages	7
Journal	Journal of Biological Regulators and Homeostatic Agents
Volume	26
Issue number	4
Publication status	Published - Oct 2012

Keywords

BNP
IUGR
Newborn infant

ASJC Scopus subject areas

Oncology
Endocrinology, Diabetes and Metabolism
Physiology (medical)
Immunology and Allergy
Immunology
Endocrinology
Physiology
Cancer Research

Cite this

Garofoli, F., Mannarino, S., Montanari, L., Cerbo, R., Tzialla, C., Mazzucchelli, I., Angelini, M., Codazzi, A. C., Mongini, M. E., Manzoni, P., Tinelli, C., Spinillo, A., & Stronati, M. (2012). Variation of B-type natriuretic peptide concentrations and intrauterine growth restriction: Mother, fetus and newborn. Journal of Biological Regulators and Homeostatic Agents, 26(4), 733-739.

Garofoli, F, Mannarino, S, Montanari, L, Cerbo, R , Tzialla, C, Mazzucchelli, I, Angelini, M , Codazzi, AC , Mongini, ME, Manzoni, P, Tinelli, C , Spinillo, A & Stronati, M 2012, 'Variation of B-type natriuretic peptide concentrations and intrauterine growth restriction: Mother, fetus and newborn', Journal of Biological Regulators and Homeostatic Agents, vol. 26, no. 4, pp. 733-739.

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abstract = "To evaluate maternal, fetal, neonatal B-type natriuretic peptide (BNP) concentrations related to Intra Uterine Growth Restriction (IUGR). BNP concentrations in 43 IUGR and 35 healthy, Appropriate for Gestational Age (AGA) infants/paired mothers have been compared, from delivery/birth to first month of life. Maternal and IUGR cord BNP concentrations were coupled to fetal ultrasonography. Neonatal echocardiography was performed too. On delivery BNP was higher in all IUGR mothers, suffering or not from gestational hypertension, than in AGA (median 37.14 vs 11.1 pg/ml p=0.002). Maternal BNP was not associated to cord/neonatal BNP or fetal ultrasonographic parameters. Cord BNP was higher in IUGR than AGA newborns (median 23.9 vs 11.4 pg/ml p=0.0007) independently of gestational age, while varied with amniotic fluid (p=0.0044) and umbilical artery flowmetry (p=0.0121). Earlier drop of BNP on day 3 was reported in IUGR neonates (p=0.0001). Ventricular mass change/body weight varied positively in AGA newborns (p",

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AU - Angelini, M.

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Variation of B-type natriuretic peptide concentrations and intrauterine growth restriction: Mother, fetus and newborn

Abstract

Keywords

ASJC Scopus subject areas

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