Validation of the modified TNM-Izumi classification for hepatocellular carcinoma

Carlo Staudacher, Antonio Chiappa, Francesca Biella, Riccardo A. Audisio, Emilio Bertani, Andrew P. Zbar

Research output: Contribution to journalArticlepeer-review


Aims and background: The clinical value of the UICC TNM classification and the Izumi TNM modification regarding prognosis after hepatic resection was evaluated. Methods: Between January 1993 and December 1998, survival and disease-free survival were analyzed in 53 cirrhotic patients (40 males, 13 females; mean age, 65 years; range, 43-81) who underwent hepatic resection for HCC. Results: The 1-, 3-, and 5-year overall survivals were: 89%, 54%, and 50%, with disease-free survivals of 70%, 38%, and 28%, respectively. The difference between stages 1 and 2 or stages 3 and 4A using the UICC TNM classification was not significant with respect to survival or disease-free survival. Conversely, the Izumi TNM modification showed a significant difference between each stage with respect to survival and disease-free survival. In a multivariate analysis the lack of micro/macro vascular invasion was predictive of long-term outcome. Conclusions: Our results show that the UICC TNM classification for hepatocellular carcinoma is inadequate. The Izumi modified TNM staging system is superior in assessing prognosis for surgical HCC patients.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
Issue number1
Publication statusPublished - Jan 2000


  • Cirrhosis
  • Hepatocellular carcinoma
  • Prognostic factors
  • UICC TNM classification

ASJC Scopus subject areas

  • Cancer Research


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