Use of a fully-resorbable, biomimetic composite hydroxyapatite as bone graft substitute for posterolateral spine fusion: A case report

Brunella Grigolo, Paolo Dolzani, Christian Giannetti, Miria Tenucci, Giuseppe Calvosa

Research output: Contribution to journalArticlepeer-review


Introduction: A successful spinal fusion is the result of the proper integration between the fixation device, used to stabilize and correct the column posture, and the bone graft applied to replace or integrate the bone components. Background: In the recent past, the use of bone graft substitutes has been widely employed in spinal stabilization surgery, with the aim of improving the amount of bone graft material available, as well as to avoid the use of autograft and allograft bone, with related drawbacks and side-effects. However, since standardized non-invasive techniques (X-rays, CT scan images) are no sufficiently accurate in predicting whether bony fusion occurred, currently the only option to evaluate the bone graft osteointeointegration is through a revision surgery, due to the need of correcting the previous surgical procedure. Here, we present the osteointegrative properties of a third-generation hydroxyapatite bone graft substitute applied on a 65-year-old patient, who underwent a spinal stabilization surgery and, one year later, a revision surgery due to the rupture of a metallic bar. Materials and Methods: Bony fusion was evaluated by histological and immunohistochemical analysis performed on a biopsy sample one year after surgery. For this purpose, histological and immunohistochemical analysis were performed. Results: Histological analysis clearly evidenced the complete osteointegration of the device, together with new bone formation. Discussion and Conclusions: Third-generation bone graft substitutes allow bone ingrowth and tissue remodelling by providing three-dimensional structural support, thus resulting as ideal scaffolds for bone replacement and osteointegration.

Original languageEnglish
Article numberIJCEM0032882
Pages (from-to)22458-22462
Number of pages5
JournalInternational Journal of Clinical and Experimental Medicine
Issue number11
Publication statusPublished - Dec 20 2016


  • Arthrodesis
  • Bone grafts
  • Hydroxyapatite
  • Osteointegration
  • Posterolateral spine fusion
  • Spinal stabilization

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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