Urinary p-cresol is elevated in small children with severe autism spectrum disorder

Laura Altieri; Cristina Neri; Roberto Sacco; Paolo Curatolo; Arianna Benvenuto; Filippo Muratori; Elisa Santocchi; Carmela Bravaccio; Carlo Lenti; Monica Saccani; Roberto Rigardetto; Marina Gandione; Andrea Urbani; Antonio M. Persico

doi:10.3109/1354750X.2010.548010

Urinary p-cresol is elevated in small children with severe autism spectrum disorder

Laura Altieri, Cristina Neri, Roberto Sacco, Paolo Curatolo, Arianna Benvenuto, Filippo Muratori, Elisa Santocchi, Carmela Bravaccio, Carlo Lenti, Monica Saccani, Roberto Rigardetto, Marina Gandione, Andrea Urbani, Antonio M. Persico

Research output: Contribution to journal › Article › peer-review

Abstract

Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p

Original language	English
Pages (from-to)	252-260
Number of pages	9
Journal	Biomarkers
Volume	16
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2010.548010
Publication status	Published - May 2011

Keywords

Clostridium
cotinine
gut flora
organic contaminants
pervasive developmental disorders

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2010.548010

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abstract = "Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p",

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AU - Altieri, Laura

AU - Neri, Cristina

AU - Sacco, Roberto

AU - Curatolo, Paolo

AU - Benvenuto, Arianna

AU - Muratori, Filippo

AU - Santocchi, Elisa

AU - Bravaccio, Carmela

AU - Lenti, Carlo

AU - Saccani, Monica

AU - Rigardetto, Roberto

AU - Gandione, Marina

AU - Urbani, Andrea

AU - Persico, Antonio M.

PY - 2011/5

Y1 - 2011/5

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KW - Clostridium

KW - cotinine

KW - gut flora

KW - organic contaminants

KW - pervasive developmental disorders

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Urinary p-cresol is elevated in small children with severe autism spectrum disorder

Abstract

Keywords

ASJC Scopus subject areas

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