Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis

Carolina Scagnolari; Fabio Midulla; Simona Trombetti; Alessandra Pierangeli; Valeria Tromba; Rosanna Grossi; Paola Di Marco; Caterina Dianzani; Enrico Girardi; Guido Antonelli

doi:10.3181/0705-BC-124

Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis

Carolina Scagnolari, Fabio Midulla, Simona Trombetti, Alessandra Pierangeli, Valeria Tromba, Rosanna Grossi, Paola Di Marco, Caterina Dianzani, Enrico Girardi, Guido Antonelli

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.

Original language	English
Pages (from-to)	1355-1359
Number of pages	5
Journal	Experimental Biology and Medicine
Volume	232
Issue number	10
DOIs	https://doi.org/10.3181/0705-BC-124
Publication status	Published - Nov 2007

Keywords

2-5 OAS
Bronchiolitis
Interferon
P56
PKR
Rhinovirus
RSV

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.3181/0705-BC-124

Cite this

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abstract = "To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.",

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AU - Scagnolari, Carolina

AU - Midulla, Fabio

AU - Trombetti, Simona

AU - Pierangeli, Alessandra

AU - Tromba, Valeria

AU - Grossi, Rosanna

AU - Di Marco, Paola

AU - Dianzani, Caterina

AU - Girardi, Enrico

AU - Antonelli, Guido

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AB - To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.

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KW - Interferon

KW - P56

KW - PKR

KW - Rhinovirus

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Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis

Abstract

Keywords

ASJC Scopus subject areas

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