Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer

Stefano Filippo Zorzi; Maria Silvia Lazio; Giacomo Pietrobon; Francesco Chu; Valeria Zurlo; Debora Bibiano; Luigi De Benedetto; Augusto Cattaneo; Rita De Berardinis; Chiara Mossinelli; Daniela Alterio; Maria Cossu Rocca; Sara Gandini; Oreste Gallo; Susanna Chiocca; Marta Tagliabue; Mohssen Ansarin

doi:10.1016/j.amjoto.2021.103272

Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer

Stefano Filippo Zorzi, Maria Silvia Lazio, Giacomo Pietrobon, Francesco Chu, Valeria Zurlo, Debora Bibiano, Luigi De Benedetto, Augusto Cattaneo, Rita De Berardinis, Chiara Mossinelli, Daniela Alterio, Maria Cossu Rocca, Sara Gandini, Oreste Gallo, Susanna Chiocca, Marta Tagliabue, Mohssen Ansarin

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer.

MATERIALS AND METHODS: We collected clinical data of patients submitted to open partial horizontal laryngectomies (OPHLs) and any possible adjuvant treatment from 2005 to 2018. Outcomes were also compared to the most recent studies reporting on both medical and surgical organ-preservation strategies.

RESULTS: One hundred ten patients were included in the analysis. Adjuvant therapy was employed in 51% of cases. The local control rate was 96.4%, while overall survival (OS) was 67%, and laryngo-esophageal dysfunction free survival (LEDFS) was 66%. Stage IV and vascular invasion were associated with a statistically-significant worse survival.

CONCLUSIONS: OPHLs are valid as upfront treatment in fit patients affected by advanced-stage laryngeal cancer. Disease control and function preservation are granted in a significant percentage of cases, even when followed by adjuvant therapy.

Original language	English
Pages (from-to)	103272
Journal	American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.amjoto.2021.103272
Publication status	Published - Jan 2022

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Zorzi, S. F., Lazio, M. S., Pietrobon, G., Chu, F., Zurlo, V., Bibiano, D., De Benedetto, L., Cattaneo, A., De Berardinis, R., Mossinelli, C., Alterio, D., Rocca, M. C., Gandini, S., Gallo, O., Chiocca, S., Tagliabue, M., & Ansarin, M. (2022). Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer. American Journal of Otolaryngology - Head and Neck Medicine and Surgery, 43(1), 103272. https://doi.org/10.1016/j.amjoto.2021.103272

Zorzi, SF, Lazio, MS, Pietrobon, G , Chu, F , Zurlo, V, Bibiano, D, De Benedetto, L , Cattaneo, A , De Berardinis, R , Mossinelli, C , Alterio, D , Rocca, MC , Gandini, S, Gallo, O, Chiocca, S , Tagliabue, M & Ansarin, M 2022, 'Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 43, no. 1, pp. 103272. https://doi.org/10.1016/j.amjoto.2021.103272

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title = "Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer",

abstract = "PURPOSE: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer.MATERIALS AND METHODS: We collected clinical data of patients submitted to open partial horizontal laryngectomies (OPHLs) and any possible adjuvant treatment from 2005 to 2018. Outcomes were also compared to the most recent studies reporting on both medical and surgical organ-preservation strategies.RESULTS: One hundred ten patients were included in the analysis. Adjuvant therapy was employed in 51% of cases. The local control rate was 96.4%, while overall survival (OS) was 67%, and laryngo-esophageal dysfunction free survival (LEDFS) was 66%. Stage IV and vascular invasion were associated with a statistically-significant worse survival.CONCLUSIONS: OPHLs are valid as upfront treatment in fit patients affected by advanced-stage laryngeal cancer. Disease control and function preservation are granted in a significant percentage of cases, even when followed by adjuvant therapy.",

author = "Zorzi, {Stefano Filippo} and Lazio, {Maria Silvia} and Giacomo Pietrobon and Francesco Chu and Valeria Zurlo and Debora Bibiano and {De Benedetto}, Luigi and Augusto Cattaneo and {De Berardinis}, Rita and Chiara Mossinelli and Daniela Alterio and Rocca, {Maria Cossu} and Sara Gandini and Oreste Gallo and Susanna Chiocca and Marta Tagliabue and Mohssen Ansarin",

year = "2022",

month = jan,

doi = "10.1016/j.amjoto.2021.103272",

language = "English",

volume = "43",

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T1 - Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer

AU - Zorzi, Stefano Filippo

AU - Lazio, Maria Silvia

AU - Pietrobon, Giacomo

AU - Chu, Francesco

AU - Zurlo, Valeria

AU - Bibiano, Debora

AU - De Benedetto, Luigi

AU - Cattaneo, Augusto

AU - De Berardinis, Rita

AU - Mossinelli, Chiara

AU - Alterio, Daniela

AU - Rocca, Maria Cossu

AU - Gandini, Sara

AU - Gallo, Oreste

AU - Chiocca, Susanna

AU - Tagliabue, Marta

AU - Ansarin, Mohssen

PY - 2022/1

Y1 - 2022/1

N2 - PURPOSE: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer.MATERIALS AND METHODS: We collected clinical data of patients submitted to open partial horizontal laryngectomies (OPHLs) and any possible adjuvant treatment from 2005 to 2018. Outcomes were also compared to the most recent studies reporting on both medical and surgical organ-preservation strategies.RESULTS: One hundred ten patients were included in the analysis. Adjuvant therapy was employed in 51% of cases. The local control rate was 96.4%, while overall survival (OS) was 67%, and laryngo-esophageal dysfunction free survival (LEDFS) was 66%. Stage IV and vascular invasion were associated with a statistically-significant worse survival.CONCLUSIONS: OPHLs are valid as upfront treatment in fit patients affected by advanced-stage laryngeal cancer. Disease control and function preservation are granted in a significant percentage of cases, even when followed by adjuvant therapy.

AB - PURPOSE: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer.MATERIALS AND METHODS: We collected clinical data of patients submitted to open partial horizontal laryngectomies (OPHLs) and any possible adjuvant treatment from 2005 to 2018. Outcomes were also compared to the most recent studies reporting on both medical and surgical organ-preservation strategies.RESULTS: One hundred ten patients were included in the analysis. Adjuvant therapy was employed in 51% of cases. The local control rate was 96.4%, while overall survival (OS) was 67%, and laryngo-esophageal dysfunction free survival (LEDFS) was 66%. Stage IV and vascular invasion were associated with a statistically-significant worse survival.CONCLUSIONS: OPHLs are valid as upfront treatment in fit patients affected by advanced-stage laryngeal cancer. Disease control and function preservation are granted in a significant percentage of cases, even when followed by adjuvant therapy.

U2 - 10.1016/j.amjoto.2021.103272

DO - 10.1016/j.amjoto.2021.103272

M3 - Article

C2 - 34757315

SN - 0196-0709

VL - 43

SP - 103272

JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

IS - 1

ER -

Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer

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