TY - JOUR
T1 - Unusual presentation of large B cell lymphoma
T2 - A case report and review of literature
AU - Airaghi, L.
AU - Greco, I.
AU - Carrabba, M.
AU - Barcella, M.
AU - Baldini, I. M.
AU - Bonara, P.
AU - Goldaniga, M.
AU - Baldini, L.
PY - 2006/10
Y1 - 2006/10
N2 - Diffuse large B cell lymphoma (DLBCL) is the largest subtype of non-Hodgkin's lymphomas (NHLs) and is characterized by relatively frequent extranodal presentation. In these cases, the most common extranodal localizations are stomach, CNS, bone, testis and liver. Simultaneous detection of multiple extranodal involvement at presentation is quite uncommon, with the majority of these cases characterized by gastric or intestinal disease localization. Retrospective analysis concerning multifocal extranodal NHLs never pointed out disease features such as those described here. We report a patient with an unusual presentation of DLBCL, characterized by adrenal and renal involvement, associated with symptoms and signs of the cold agglutinin disease and a hypercoagulable state. Subsequently, computed tomography (CT) and fluorodeoxyglucose-positron emission tomography (FDG-PET) scanning disclosed a rapidly extensive spread to nodes and bones. Cytofluorimetric analysis of a renal specimen showed medium-to-large lympho-monocytoid elements positive for CD20 with monoclonal expression of immunoglobulin kappa light chain. Histopathological examination confirmed a renal CD20 positive DLBCL localization.
AB - Diffuse large B cell lymphoma (DLBCL) is the largest subtype of non-Hodgkin's lymphomas (NHLs) and is characterized by relatively frequent extranodal presentation. In these cases, the most common extranodal localizations are stomach, CNS, bone, testis and liver. Simultaneous detection of multiple extranodal involvement at presentation is quite uncommon, with the majority of these cases characterized by gastric or intestinal disease localization. Retrospective analysis concerning multifocal extranodal NHLs never pointed out disease features such as those described here. We report a patient with an unusual presentation of DLBCL, characterized by adrenal and renal involvement, associated with symptoms and signs of the cold agglutinin disease and a hypercoagulable state. Subsequently, computed tomography (CT) and fluorodeoxyglucose-positron emission tomography (FDG-PET) scanning disclosed a rapidly extensive spread to nodes and bones. Cytofluorimetric analysis of a renal specimen showed medium-to-large lympho-monocytoid elements positive for CD20 with monoclonal expression of immunoglobulin kappa light chain. Histopathological examination confirmed a renal CD20 positive DLBCL localization.
KW - Cold agglutinin disease
KW - Diffuse large B cell lymphoma
KW - Extranodal disease
KW - Primary adrenal lymphoma
KW - Primary renal lymphoma
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U2 - 10.1111/j.1365-2257.2006.00816.x
DO - 10.1111/j.1365-2257.2006.00816.x
M3 - Article
C2 - 16999726
AN - SCOPUS:33749036291
SN - 0141-9854
VL - 28
SP - 338
EP - 342
JO - Clinical and Laboratory Haematology
JF - Clinical and Laboratory Haematology
IS - 5
ER -