TY - JOUR
T1 - Unrelated cord blood compared with haploidentical grafts in patients with hematological malignancies
AU - El-Cheikh, Jean
AU - Crocchiolo, Roberto
AU - Furst, Sabine
AU - Bramanti, Stefania
AU - Sarina, Barbara
AU - Granata, Angela
AU - Vai, Andrea
AU - Lemarie, Claude
AU - Faucher, Catherine
AU - Mohty, Bilal
AU - Harbi, Samia
AU - Bouabdallah, Reda
AU - Vey, Norbert
AU - Santoro, Armando
AU - Chabannon, Christian
AU - Castagna, Luca
AU - Blaise, Didier
PY - 2015/6/1
Y1 - 2015/6/1
N2 - BACKGROUND Alternative donors, such as unrelated umbilical cord blood (UCB) and related haploidentical (haplo) donors, are more and more frequently searched for and used for patients who are candidates for allogeneic hematopoietic stem cell transplantation but are without a suitable related or unrelated donor. The aim of the current retrospective study was to compare the outcome of patients after haplo and UCB grafts prepared using a nonmyeloablative conditioning regimen. METHODS A total of 150 adult patients with high-risk hematologic diseases who underwent allogeneic hematopoietic stem cell transplantation from alternative donors at 2 centers (Paoli-Calmettes Institute [Marseille, France] and Humanitas Cancer Center [Milan, Italy]) were analyzed. Sixty-nine patients had haplo donors and 81 patients had UCB donors. RESULTS The cumulative incidence of nonrecurrence mortality at 1 year was 23% in the UCB group versus 17% in the haplo group (P-=-.39). The incidence of grade 2 to 4 acute graft-versus-host disease and extensive chronic graft-versus-host disease in the UCB group versus the haplo group was 52% versus 29% (P-=-.05) and 12% versus 6% (P
AB - BACKGROUND Alternative donors, such as unrelated umbilical cord blood (UCB) and related haploidentical (haplo) donors, are more and more frequently searched for and used for patients who are candidates for allogeneic hematopoietic stem cell transplantation but are without a suitable related or unrelated donor. The aim of the current retrospective study was to compare the outcome of patients after haplo and UCB grafts prepared using a nonmyeloablative conditioning regimen. METHODS A total of 150 adult patients with high-risk hematologic diseases who underwent allogeneic hematopoietic stem cell transplantation from alternative donors at 2 centers (Paoli-Calmettes Institute [Marseille, France] and Humanitas Cancer Center [Milan, Italy]) were analyzed. Sixty-nine patients had haplo donors and 81 patients had UCB donors. RESULTS The cumulative incidence of nonrecurrence mortality at 1 year was 23% in the UCB group versus 17% in the haplo group (P-=-.39). The incidence of grade 2 to 4 acute graft-versus-host disease and extensive chronic graft-versus-host disease in the UCB group versus the haplo group was 52% versus 29% (P-=-.05) and 12% versus 6% (P
KW - allogeneic hematopoietic stem cell transplantation
KW - haploidentical donor
KW - high-risk hematological diseases
KW - nonmyeloablative conditioning regimen
KW - unrelated umbilical cord blood
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U2 - 10.1002/cncr.29271
DO - 10.1002/cncr.29271
M3 - Article
C2 - 25649994
AN - SCOPUS:84929656135
SN - 0008-543X
VL - 121
SP - 1809
EP - 1816
JO - Cancer
JF - Cancer
IS - 11
ER -