Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling

Matteo Piazza; Miriam Colombo; Ivan Zanoni; Francesca Granucci; Paolo Tortora; Jerrold Weiss; Theresa Gioannini; Davide Prosperi; Francesco Peri

doi:10.1002/anie.201004655

Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling

Matteo Piazza, Miriam Colombo, Ivan Zanoni, Francesca Granucci, Paolo Tortora, Jerrold Weiss, Theresa Gioannini, Davide Prosperi, Francesco Peri

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture).

Original language	English
Pages (from-to)	622-626
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	3
DOIs	https://doi.org/10.1002/anie.201004655
Publication status	Published - Jan 17 2011

Keywords

endotoxin
immunology
lipopolysaccharides
nanoparticles
receptors

ASJC Scopus subject areas

Chemistry(all)
Catalysis

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10.1002/anie.201004655

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abstract = "Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture).",

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AU - Colombo, Miriam

AU - Zanoni, Ivan

AU - Granucci, Francesca

AU - Tortora, Paolo

AU - Weiss, Jerrold

AU - Gioannini, Theresa

AU - Prosperi, Davide

AU - Peri, Francesco

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AB - Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture).

KW - endotoxin

KW - immunology

KW - lipopolysaccharides

KW - nanoparticles

KW - receptors

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Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling

Abstract

Keywords

ASJC Scopus subject areas

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