TY - JOUR
T1 - Unexpected low expression of platelet fibrinogen receptor in patients with chronic myeloproliferative neoplasms
T2 - how does it change with aspirin?
AU - Lucchesi, Alessandro
AU - Carloni, Silvia
AU - De Matteis, Serena
AU - Ghetti, Martina
AU - Musuraca, Gerardo
AU - Poggiaspalla, Monica
AU - Augello, Accursio F.
AU - Giordano, Giulio
AU - Fattori, Pier P.
AU - Martinelli, Giovanni
AU - Napolitano, Roberta
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This study was conducted to evaluate the expression of fibrinogen receptors on platelets of Philadelphia-negative chronic myeloproliferative neoplasm (MPN) patients. We collected blood samples from 40 consecutive MPN patients and healthy volunteers. We performed flow cytometry analysis of P-selectin expression and integrin beta-3, activation of glycoprotein (GP) IIb/IIIa and fibrinogen receptor exposure (PAC-1 binding). Surprisingly, we found a very low PAC-1 binding capacity in MPN patients; however, the expression of PAC-1 was almost completely recovered with aspirin intake. We hypothesize that the hypercoagulable states observed in MPN patients could depend on a primarily plasma-driven impairment of fibrin turnover and thrombin generation.
AB - This study was conducted to evaluate the expression of fibrinogen receptors on platelets of Philadelphia-negative chronic myeloproliferative neoplasm (MPN) patients. We collected blood samples from 40 consecutive MPN patients and healthy volunteers. We performed flow cytometry analysis of P-selectin expression and integrin beta-3, activation of glycoprotein (GP) IIb/IIIa and fibrinogen receptor exposure (PAC-1 binding). Surprisingly, we found a very low PAC-1 binding capacity in MPN patients; however, the expression of PAC-1 was almost completely recovered with aspirin intake. We hypothesize that the hypercoagulable states observed in MPN patients could depend on a primarily plasma-driven impairment of fibrin turnover and thrombin generation.
KW - aspirin
KW - myeloproliferative neoplasms
KW - PAC-1
KW - platelet fibrinogen receptor
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U2 - 10.1111/bjh.16335
DO - 10.1111/bjh.16335
M3 - Article
C2 - 31792942
AN - SCOPUS:85076309836
SN - 0007-1048
JO - British Journal of Haematology
JF - British Journal of Haematology
ER -