TY - JOUR
T1 - Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
AU - Hideshima, Teru
AU - Mitsiades, Constantine
AU - Tonon, Giovanni
AU - Richardson, Paul G.
AU - Anderson, Kenneth C.
PY - 2007/8/19
Y1 - 2007/8/19
N2 - Multiple myeloma is a plasma cell malignancy characterized by complex heterogeneous cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies. Although multiple myeloma remains incurable, novel targeted agents, used alone or in combination, have shown great promise to overcome conventional drug resistance and improve patient outcome. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma, providing the framework for new prognostic classification and identifying new therapeutic targets.
AB - Multiple myeloma is a plasma cell malignancy characterized by complex heterogeneous cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies. Although multiple myeloma remains incurable, novel targeted agents, used alone or in combination, have shown great promise to overcome conventional drug resistance and improve patient outcome. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma, providing the framework for new prognostic classification and identifying new therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=34547106018&partnerID=8YFLogxK
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U2 - 10.1038/nrc2189
DO - 10.1038/nrc2189
M3 - Article
C2 - 17646864
AN - SCOPUS:34547106018
SN - 1474-175X
VL - 7
SP - 585
EP - 598
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -