Ultrastructural localization of alpha-naphthyl acid esterase in human T(M) lymphocytes

A. Zicca, A. Leprini, A. Cadoni, A. T. Franzi, M. Ferrarini, C. E. Grossi

Research output: Contribution to journalArticlepeer-review


The localization of alpha-naphthyl acid esterase (ANAE) activity in T lymphocytes with receptors for IgM (T(M) cells) have been studied at the electron microsope. The electron-opaque product of the cytochemical reaction was detected around, but never inside, single (or groups of) vesicles, which suggested a possible membrane localization of the enzyme activity. These same vesicles were found to contain acid phosphatase by both light- and electron-microscopic examination and were bound by unit membranes; this data indicates that they likely represent primary lysosomes. The presence of such lysosomes in a restricted paranuclear area is a distinctive feature of T(M) cells.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalAmerican Journal of Pathology
Issue number1
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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