TY - JOUR
T1 - Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC)
T2 - A case report
AU - Tiseo, Marcello
AU - Gelsomino, Francesco
AU - Bartolotti, Marco
AU - Barili, Matteo Pesenti
AU - Ardizzoni, Andrea
PY - 2009/8
Y1 - 2009/8
N2 - Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors. We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.
AB - Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors. We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.
KW - Chemotherapy
KW - Neutropenia
KW - Non-small cell lung cancer
KW - Pemetrexed
KW - Second line
KW - Typhlitis
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U2 - 10.1016/j.lungcan.2009.02.021
DO - 10.1016/j.lungcan.2009.02.021
M3 - Article
C2 - 19346026
AN - SCOPUS:67449149696
SN - 0169-5002
VL - 65
SP - 251
EP - 253
JO - Lung Cancer
JF - Lung Cancer
IS - 2
ER -