Two-year treatment with oral contraceptives in hyperprolactinemic patients

Giovanna Testa; Walter Vegetti; Tiziano Motta; Federica Alagna; Diana Bianchedi; Clelia Carlucci; Massimiliano Bianchi; Fabio Parazzini; Pier Giorgio Crosignani

doi:10.1016/S0010-7824(98)00069-9

Two-year treatment with oral contraceptives in hyperprolactinemic patients

Giovanna Testa, Walter Vegetti, Tiziano Motta, Federica Alagna, Diana Bianchedi, Clelia Carlucci, Massimiliano Bianchi, Fabio Parazzini, Pier Giorgio Crosignani

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituitary microadenoma) who started OC use were admitted in the study. After 2 years of OC use, the assessable patients showed a nonsignificant decrease in plasma PRL level (26.8 ± 29.4 μg/mL, range 4.2-97.1 μg/mL vs 56.3 ± 31.5 μg/mL, range 23.5-144 μg/mL). No patient experienced any radiological changes during OC treatment. In conclusion, although the number of observations is limited, the data suggest that after 2 years of follow-up, no harmful effect of OC use was observed in these patients.

Original language	English
Pages (from-to)	69-73
Number of pages	5
Journal	Contraception
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/S0010-7824(98)00069-9
Publication status	Published - Aug 1998

Keywords

Hyperprolactinemia
Microadenoma
Oral contraception
Pituitary
Prospective study

ASJC Scopus subject areas

Medicine(all)
Obstetrics and Gynaecology

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10.1016/S0010-7824(98)00069-9

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title = "Two-year treatment with oral contraceptives in hyperprolactinemic patients",

abstract = "The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituitary microadenoma) who started OC use were admitted in the study. After 2 years of OC use, the assessable patients showed a nonsignificant decrease in plasma PRL level (26.8 ± 29.4 μg/mL, range 4.2-97.1 μg/mL vs 56.3 ± 31.5 μg/mL, range 23.5-144 μg/mL). No patient experienced any radiological changes during OC treatment. In conclusion, although the number of observations is limited, the data suggest that after 2 years of follow-up, no harmful effect of OC use was observed in these patients.",

keywords = "Hyperprolactinemia, Microadenoma, Oral contraception, Pituitary, Prospective study",

author = "Giovanna Testa and Walter Vegetti and Tiziano Motta and Federica Alagna and Diana Bianchedi and Clelia Carlucci and Massimiliano Bianchi and Fabio Parazzini and Crosignani, {Pier Giorgio}",

year = "1998",

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doi = "10.1016/S0010-7824(98)00069-9",

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AU - Testa, Giovanna

AU - Vegetti, Walter

AU - Motta, Tiziano

AU - Alagna, Federica

AU - Bianchedi, Diana

AU - Carlucci, Clelia

AU - Bianchi, Massimiliano

AU - Parazzini, Fabio

AU - Crosignani, Pier Giorgio

PY - 1998/8

Y1 - 1998/8

N2 - The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituitary microadenoma) who started OC use were admitted in the study. After 2 years of OC use, the assessable patients showed a nonsignificant decrease in plasma PRL level (26.8 ± 29.4 μg/mL, range 4.2-97.1 μg/mL vs 56.3 ± 31.5 μg/mL, range 23.5-144 μg/mL). No patient experienced any radiological changes during OC treatment. In conclusion, although the number of observations is limited, the data suggest that after 2 years of follow-up, no harmful effect of OC use was observed in these patients.

AB - The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituitary microadenoma) who started OC use were admitted in the study. After 2 years of OC use, the assessable patients showed a nonsignificant decrease in plasma PRL level (26.8 ± 29.4 μg/mL, range 4.2-97.1 μg/mL vs 56.3 ± 31.5 μg/mL, range 23.5-144 μg/mL). No patient experienced any radiological changes during OC treatment. In conclusion, although the number of observations is limited, the data suggest that after 2 years of follow-up, no harmful effect of OC use was observed in these patients.

KW - Hyperprolactinemia

KW - Microadenoma

KW - Oral contraception

KW - Pituitary

KW - Prospective study

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Two-year treatment with oral contraceptives in hyperprolactinemic patients

Abstract

Keywords

ASJC Scopus subject areas

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