Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host

F. Delaini; R. Giavazzi; G. de Bellis Vitti; G. Alessandri; A. Mantovani; M. B. Donati

doi:10.1038/bjc.1981.14

Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host

F. Delaini, R. Giavazzi, G. de Bellis Vitti, G. Alessandri, A. Mantovani, M. B. Donati

Research output: Contribution to journal › Article › peer-review

Abstract

This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	British Journal of Cancer
Volume	43
Issue number	1
DOIs	https://doi.org/10.1038/bjc.1981.14
Publication status	Published - 1981

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/bjc.1981.14

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abstract = "This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.",

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AU - Delaini, F.

AU - Giavazzi, R.

AU - de Bellis Vitti, G.

AU - Alessandri, G.

AU - Mantovani, A.

AU - Donati, M. B.

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N2 - This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.

AB - This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.

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Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host

Abstract

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