Tumour necrosis factor enhances the therapeutic effect of mitoxantrone in human ovarian cancer xenograft

Elvira Noviello; Guido Cimoli; Alessandro Cosimi; Enrico Allievi; Piergiorgio Galletti; Silvio Parodi; Patrizia Russo

doi:10.1006/cyto.1996.0045

Tumour necrosis factor enhances the therapeutic effect of mitoxantrone in human ovarian cancer xenograft

Elvira Noviello, Guido Cimoli, Alessandro Cosimi, Enrico Allievi, Piergiorgio Galletti, Silvio Parodi, Patrizia Russo

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

The combination of Tumour Necrosis Factor (TNF) and mitoxantrone was evaluated for potential chemotherapeutic effect against a human ovarian cancer cell line A2774 heterotransplanted in female nude mice. Both antitumour efficacy (relative survival and reduction of ascites) and toxicity (weight loss and liver toxicity) of TNF alone, mitoxantrone alone or TNF + mitoxantrone were evaluated. A significative difference (P <0.002) was observed only among animals bearing tumours treated with mitoxantrone (0.012 mg/Kg) + TNF (5 x 10⁵ U/Kg) and controls. No cytotoxic effects were observed for this combination. These observations provide a rationale for further evaluation of TNF + mitoxantrone based regimes for the treatment of recurrent ovarian cancer.

Original language	English
Pages (from-to)	330-333
Number of pages	4
Journal	Cytokine
Volume	8
Issue number	4
DOIs	https://doi.org/10.1006/cyto.1996.0045
Publication status	Published - Apr 1996

Keywords

Mitoxantrone
Nude mice
Ovarian cancer
Therapeutic effect
TNF

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Immunology
Immunology and Allergy

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10.1006/cyto.1996.0045

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abstract = "The combination of Tumour Necrosis Factor (TNF) and mitoxantrone was evaluated for potential chemotherapeutic effect against a human ovarian cancer cell line A2774 heterotransplanted in female nude mice. Both antitumour efficacy (relative survival and reduction of ascites) and toxicity (weight loss and liver toxicity) of TNF alone, mitoxantrone alone or TNF + mitoxantrone were evaluated. A significative difference (P <0.002) was observed only among animals bearing tumours treated with mitoxantrone (0.012 mg/Kg) + TNF (5 x 105 U/Kg) and controls. No cytotoxic effects were observed for this combination. These observations provide a rationale for further evaluation of TNF + mitoxantrone based regimes for the treatment of recurrent ovarian cancer.",

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AU - Noviello, Elvira

AU - Cimoli, Guido

AU - Cosimi, Alessandro

AU - Allievi, Enrico

AU - Galletti, Piergiorgio

AU - Parodi, Silvio

AU - Russo, Patrizia

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N2 - The combination of Tumour Necrosis Factor (TNF) and mitoxantrone was evaluated for potential chemotherapeutic effect against a human ovarian cancer cell line A2774 heterotransplanted in female nude mice. Both antitumour efficacy (relative survival and reduction of ascites) and toxicity (weight loss and liver toxicity) of TNF alone, mitoxantrone alone or TNF + mitoxantrone were evaluated. A significative difference (P <0.002) was observed only among animals bearing tumours treated with mitoxantrone (0.012 mg/Kg) + TNF (5 x 105 U/Kg) and controls. No cytotoxic effects were observed for this combination. These observations provide a rationale for further evaluation of TNF + mitoxantrone based regimes for the treatment of recurrent ovarian cancer.

AB - The combination of Tumour Necrosis Factor (TNF) and mitoxantrone was evaluated for potential chemotherapeutic effect against a human ovarian cancer cell line A2774 heterotransplanted in female nude mice. Both antitumour efficacy (relative survival and reduction of ascites) and toxicity (weight loss and liver toxicity) of TNF alone, mitoxantrone alone or TNF + mitoxantrone were evaluated. A significative difference (P <0.002) was observed only among animals bearing tumours treated with mitoxantrone (0.012 mg/Kg) + TNF (5 x 105 U/Kg) and controls. No cytotoxic effects were observed for this combination. These observations provide a rationale for further evaluation of TNF + mitoxantrone based regimes for the treatment of recurrent ovarian cancer.

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KW - Ovarian cancer

KW - Therapeutic effect

KW - TNF

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Tumour necrosis factor enhances the therapeutic effect of mitoxantrone in human ovarian cancer xenograft

Abstract

Keywords

ASJC Scopus subject areas

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