Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Paola Sacerdote; Anna T. Brinia; Luisa Locatelli; Jelena Radulovic; Alberto E. Panerai

doi:10.1159/000097188

Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Paola Sacerdote, Anna T. Brinia, Luisa Locatelli, Jelena Radulovic, Alberto E. Panerai

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

Original language	English
Pages (from-to)	357-360
Number of pages	4
Journal	NeuroImmunoModulation
Volume	1
Issue number	6
DOIs	https://doi.org/10.1159/000097188
Publication status	Published - 1994

Keywords

Cytokines
Pituitary
Proopiomelanocortin
Tumor necrosis factor α
β-Endorphin

ASJC Scopus subject areas

Endocrinology
Immunology
Endocrine and Autonomic Systems
Neurology
Neuroscience(all)

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10.1159/000097188

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title = "Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo",

abstract = "We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.",

keywords = "Cytokines, Pituitary, Proopiomelanocortin, Tumor necrosis factor α, β-Endorphin",

author = "Paola Sacerdote and Brinia, {Anna T.} and Luisa Locatelli and Jelena Radulovic and Panerai, {Alberto E.}",

year = "1994",

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AU - Sacerdote, Paola

AU - Brinia, Anna T.

AU - Locatelli, Luisa

AU - Radulovic, Jelena

AU - Panerai, Alberto E.

PY - 1994

Y1 - 1994

N2 - We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

AB - We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

KW - Cytokines

KW - Pituitary

KW - Proopiomelanocortin

KW - Tumor necrosis factor α

KW - β-Endorphin

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Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Abstract

Keywords

ASJC Scopus subject areas

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