TY - JOUR
T1 - Tumor flare reactions and response to lenalidomide in patients with refractory classic Hodgkin lymphoma
AU - Corazzelli, Gaetano
AU - De Filippi, Rosaria
AU - Capobianco, Gaetana
AU - Frigeri, Ferdinando
AU - De Rosa, Vincenzo
AU - Iaccarino, Giancarla
AU - Russo, Filippo
AU - Arcamone, Manuela
AU - Becchimanzi, Cristina
AU - Crisci, Stefania
AU - Marcacci, Gianpaolo
AU - Amoroso, Barbara
AU - Lastoria, Secondo
AU - Pinto, Antonio
PY - 2010/1
Y1 - 2010/1
N2 - Patients with Hodgkin lymphoma (HL) failing salvage stem cell transplantation are candidates to investigational strategies. Lenalidomide represents an attractive option as it targets several signaling pathways, which regulate survival of HL cells and their microenvironmental interactions. We report the occurrence of Grades 2 and 3 tumor .are reactions in the .rst three patients entered a lenalidomide-based compassionate program for treatment-refractory HL. Flares occurred in concomitance of the scheduled week-off lenalidomide and upon withdrawal of symptomatic steroid treatment, and were associated with changes in B-cell regulatory cytokines and the concurrent expansion of polyclonal B-cells. Flares mimicked tumor progression but were effectively managed with anti-in.ammatory treatment and followed by a clinical response, suggesting that they may mirror the pleiotropic actions of lenalidomide on HL microenvironment.
AB - Patients with Hodgkin lymphoma (HL) failing salvage stem cell transplantation are candidates to investigational strategies. Lenalidomide represents an attractive option as it targets several signaling pathways, which regulate survival of HL cells and their microenvironmental interactions. We report the occurrence of Grades 2 and 3 tumor .are reactions in the .rst three patients entered a lenalidomide-based compassionate program for treatment-refractory HL. Flares occurred in concomitance of the scheduled week-off lenalidomide and upon withdrawal of symptomatic steroid treatment, and were associated with changes in B-cell regulatory cytokines and the concurrent expansion of polyclonal B-cells. Flares mimicked tumor progression but were effectively managed with anti-in.ammatory treatment and followed by a clinical response, suggesting that they may mirror the pleiotropic actions of lenalidomide on HL microenvironment.
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U2 - 10.1002/ajh.21571
DO - 10.1002/ajh.21571
M3 - Article
C2 - 20029955
AN - SCOPUS:74049139971
SN - 0361-8609
VL - 85
SP - 87
EP - 90
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 1
ER -