A retrospective study was performed to evaluate global prevalence of drug resistant Mycobacterium tuberculosis (DR-MTB) strains in HIV infected patients and prevalence of DR-MTB among II HIV patients who had already been treated (AT) against tuberculosis, compared to DR-MTB from 37 HIV patients who had never been treated (NT). Sensitivity tests of 48 MTB strains firstly isolated from sputum of 48 AIDS/ARC patients were performed on Lowenstein-Jensen medium with the proportional method. Significant differences in demographic data, number of full AIDS cases and CD4 counts were not found between AT and NT patients. A prevalence of 27.1% of DR-MTB has been found in HIV infected patients. DR-MTB were significantly more frequently found in AT patients. A history of treatment with anti-MTB medications was strongly associated with an increased risk of resistance. A shorter survival was obviously shown by patients with full AIDS but neither by patients with DR-MTB nor by previously treated patients. A strong policy for control and prevention of drug-resistant tuberculosis is urgently needed.
|Translated title of the contribution||Tuberculosis in HIV infection. Note III. The problem of chemotherapeutic resistance in M. tuberculosis|
|Number of pages||8|
|Journal||Lotta Contro la Tuberculosi e le Malattie Polmonari Sociali|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine