TY - JOUR
T1 - Triggering sleep slow waves by transcranial magnetic stimulation
AU - Massimini, Marcello
AU - Ferrarelli, Fabio
AU - Esser, Steve K.
AU - Riedner, Brady A.
AU - Huber, Reto
AU - Murphy, Michael
AU - Peterson, Michael J.
AU - Tononi, Giulio
PY - 2007/5/15
Y1 - 2007/5/15
N2 - During much of sleep, cortical neurons undergo near-synchronous slow oscillation cycles in membrane potential, which give rise to the largest spontaneous waves observed in the normal electroencephalogram (EEG). Slow oscillations underlie characteristic features of the sleep EEG, such as slow waves and spindles. Here we show that, in sleeping subjects, slow waves and spindles can be triggered noninvasively and reliably by transcranial magnetic stimulation (TMS). With appropriate stimulation parameters, each TMS pulse at
AB - During much of sleep, cortical neurons undergo near-synchronous slow oscillation cycles in membrane potential, which give rise to the largest spontaneous waves observed in the normal electroencephalogram (EEG). Slow oscillations underlie characteristic features of the sleep EEG, such as slow waves and spindles. Here we show that, in sleeping subjects, slow waves and spindles can be triggered noninvasively and reliably by transcranial magnetic stimulation (TMS). With appropriate stimulation parameters, each TMS pulse at
KW - Bistability
KW - Consciousness
KW - Electroencephalogram
KW - Perturbation
KW - Slow oscillation
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U2 - 10.1073/pnas.0702495104
DO - 10.1073/pnas.0702495104
M3 - Article
C2 - 17483481
AN - SCOPUS:34347237893
SN - 0027-8424
VL - 104
SP - 8496
EP - 8501
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 20
ER -