Treatment of rectovaginal endometriosis with the etonogestrel-releasing contraceptive implant

Simone Ferrero, Carolina Scala, Stefano Ciccarelli, Valerio Gaetano Vellone, Fabio Barra

Research output: Contribution to journalArticlepeer-review


This study aimed to investigate the efficacy of the etonogestrel (ENG)-releasing implant in treating patients with rectovaginal endometriosis. The study was based on the retrospective analysis of a prospectively collected database, including symptomatic women who had ultrasonographic diagnosis of rectovaginal endometriosis. Patients were follow-up at 6, 12 and 24 months from the insertion of the ENG-releasing implant. The intensity of pain symptoms was evaluated using a visual analog scale. The volume of the nodules was estimated by virtual organ computer-aided analysis. The Endometriosis Health Profile (EHP-30) was used to evaluate quality of life. Overall, 43 women were included in the study. The 2-year continuation rate for the ENG-releasing implant was 93.0%. The treatment quickly improved the intensity of non-menstrual pelvic pain, deep dyspareunia, dysmenorrhea, and dyschezia. At 6-month follow-up, there were improvements in all domains of the EHP-30 compared with baseline. Further improvements in the EHP-30 results were observed only in pain sub score at 12-month follow-up and in emotional well-being sub score at 24-month follow-up. At 6-month follow-up the volume of the rectovaginal nodules was significantly lower compared with baseline; a further decrease was observed at 12- and 24-month follow-up. The treatment was well tolerated.

Original languageEnglish
Pages (from-to)540-544
Number of pages5
JournalGynecological Endocrinology
Issue number6
Publication statusPublished - Jun 2020


  • Adult
  • Contraceptive Agents, Female/administration & dosage
  • Contraceptive Agents, Hormonal/administration & dosage
  • Desogestrel/administration & dosage
  • Drug Implants
  • Dysmenorrhea/drug therapy
  • Dyspareunia/drug therapy
  • Endometriosis/drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Pain Measurement
  • Pelvic Pain/drug therapy
  • Quality of Life
  • Rectal Diseases/drug therapy
  • Retrospective Studies
  • Treatment Outcome
  • Vaginal Diseases/drug therapy


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