Treatment of patients with neuropathy and anti-MAG IgM M-proteins

E. Nobile-Orazio, L. Baldini, S. Barbieri, P. Marmiroli, G. Spagnol, E. Francomano, G. Scarlato

Research output: Contribution to journalArticlepeer-review


Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalAnnals of Neurology
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Neuroscience(all)


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