Treatment of oropharyngeal candidiasis in HIV-infected children with oral fluconazole

P. Marchisio, N. Principi

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In an open, noncomparative, multicentre study the efficacy and safety of oral fluconazole was evaluated in the treatment of oropharyngeal candidiasis in children with HIV infection. Fifty-one children with a mean age of five years were enrolled. Oropharyngeal candidiasis was caused by Candida albicans in 28 cases (55 %). Fluconazole was given in a mean dosage of 3.4 mg/kg/d (range 2 to 5.6 mg/kg/d) for a mean duration of 12 days (range 6 to 28 days). By the end of treatment, 90 % of the children were clinically cured, 6 % had improved and 4 % failed to respond. Candida was eradicated in 82 % of the patients. Clinical failure occurred only in children given 3 mg/kg/d or less. Two and four weeks after therapy, clinical cure was confirmed in 88 % and 82 % of the children respectively as well as eradication in 76 % respectively. Six children experienced mild side effects (1 skin rash, 5 mild elevation of liver enzyme levels). The data show that fluconazole is safe and effective in treating oropharyngeal candidiasis in HIV-infected children.

Original languageEnglish
Pages (from-to)338-340
Number of pages3
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Issue number4
Publication statusPublished - Apr 1994

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology


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