Treatment of multivessel coronary artery disease with sirolimus-eluting stent implantation: Immediate and mid-term results

Dejan Orlic, Erminio Bonizzoni, Goran Stankovic, Flavio Airoldi, Alaide Chieffo, Nicola Corvaja, Giuseppe Sangiorgi, Massimo Ferraro, Carlo Briguori, Matteo Montorfano, Mauro Carlino, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


Objectives This study evaluated clinical outcome after multivessel stenting with sirolimus-eluting stents (SES) in unselected lesions. Background Safety and effectiveness of multivessel SES implantation is currently unknown. Methods Major adverse cardiac events (MACE) (death, myocardial infarction [MI], and repeat revascularization) were analyzed at 30 days and at 6 months after multivessel SES implantation. Results In 155 consecutive patients, 573 SES were implanted in 3.3 ± 1.3 lesions per patient. At 30 days, the cumulative MACE rate was 10.3%: 7.1% patients developed a non-Q-wave MI, 1.9% developed a Q-wave MI, 0.6% died for non-cardiac reasons, and 0.6% had a repeat revascularization. Clinical follow-up was obtained in all 112 eligible patients treated for 359 lesions at a mean time of 6.5 ± 2.2 months. The cumulative MACE rate was 22.3%: 3 (2.7%) deaths (1 for cardiac reasons), 4 (3.6%) MIs, target lesion revascularization (TLR) in 16 (14.3%) patients with 24 (6.7%) lesions. Target vessel revascularization was required in 18 (16.1%) patients due to TLR of lesions treated with SES or to disease progression (1.8% of patients). Cox regression analysis revealed total stent length per patient as the most powerful independent predictor of MACE. Overall stent thrombosis occurred in three (1.9%) patients. Conclusions Multivessel SES implantation can be safely performed on patients with complex coronary artery disease. The need for revascularization increases because of the cumulative effect of TLR on patients with multiple lesions.

Original languageEnglish
Pages (from-to)1154-1160
Number of pages7
JournalJournal of the American College of Cardiology
Issue number7
Publication statusPublished - Apr 7 2004


  • Bare metal stent
  • BMS
  • CABG
  • CK
  • Coronary artery bypass grafting
  • Creatine kinase
  • MACE
  • Major adverse cardiac events
  • MI
  • Myocardial infarction
  • PCI
  • Percutaneous coronary intervention
  • Percutaneous transluminal coronary angioplasty
  • PTCA
  • SES

ASJC Scopus subject areas

  • Nursing(all)


Dive into the research topics of 'Treatment of multivessel coronary artery disease with sirolimus-eluting stent implantation: Immediate and mid-term results'. Together they form a unique fingerprint.

Cite this