Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF

A. M. Vannucchi; A. Bosi; D. Laszlo; S. Guidi; R. Saccardi; P. Rossi-Ferrini

Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF

A. M. Vannucchi, A. Bosi, D. Laszlo, S. Guidi, R. Saccardi, P. Rossi-Ferrini

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.

Original language	English
Pages (from-to)	341-343
Number of pages	3
Journal	Haematologica
Volume	80
Issue number	4
Publication status	Published - 1995

Keywords

bone marrow transplantation
GM-CSF
graft failure
IL-3

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.",

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AU - Vannucchi, A. M.

AU - Bosi, A.

AU - Laszlo, D.

AU - Guidi, S.

AU - Saccardi, R.

AU - Rossi-Ferrini, P.

PY - 1995

Y1 - 1995

N2 - We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.

AB - We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.

KW - bone marrow transplantation

KW - GM-CSF

KW - graft failure

KW - IL-3

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ER -

Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF

Abstract

Keywords

ASJC Scopus subject areas

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