Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma

Giovanni Cristalli, Valentina Manciocco, Barbara Pichi, Laura Marucci, Giorgio Arcangeli, Stefano Telera, Giuseppe Spriano

Research output: Contribution to journalArticlepeer-review


This is a retrospective study to evaluate the outcomes and complications of combined treatment, surgery with or without adjunctive intraoperative radiotherapy, of locally advanced temporal bone squamous cell carcinoma. A series of 17 patients with locally advanced squamous cell carcinoma of the temporal bone were treated between September 2002 and February 2007. Eleven patients had primary tumors, and 6 patients had recurrences. According to the University of Pittsburgh staging system, 5 patients were stage II (T2 N0), 6 patients were stage III (5, T3 N0 and 1, T1 N1), and 6 patients were stage IV (5, T3 N2b and 1, T4 N0). All patients underwent lateral temporal bone resection and pedicle flap reconstruction. Eight patients received intraoperative and postoperative radiotherapies, 4 patients underwent postoperative radiation alone, whereas 5 patients did not receive any adjunctive treatment. Median follow-up was 29.5 months. No major complications were observed. No patients were found to have residual gross tumor. Disease-free survival was 73.3%, and overall survival was 75.6%. Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome. Postoperative radiotherapy is necessary to obtain good local control; no major adverse effects were observed in the intraoperative radiotherapy patients. The incidence of major complication is minimal after pedicle flap reconstruction.

Original languageEnglish
Pages (from-to)816-821
Number of pages6
JournalJournal of Craniofacial Surgery
Issue number3
Publication statusPublished - May 2009


  • External auditory canal
  • Intraoperative radiotherapy (IORT)
  • Petrosectomy
  • Temporal bone squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery


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