Transient focal neurologic deficits associated with hypoglycaemia in children with insulin-dependent diabetes mellitus

M. Pocecco, L. Ronfani, R. Berardi, S. Bernasconi, S. Mariani, E. Buratti, C. Milocco, E. Cacciari, S. Salardi, F. Cadario, L. Calisti, G. Cerasoli, F. Cerutti, V. Cherubini, A. Iannilli, F. Chiarelli, A. Verrotti, M. Cotellessa, M. Mazzella, A. CrinóG. De Giorgio, F. De Luca, F. Lombardo, V. De Santis, P. Banin, A. Franzese, L. Gargantini, E. Sampellegrini, D. Iafusco, F. Prisco, R. Lorini, G. D'Annunzio, L. Lucentini, G. Marietti, A. Marsciani, M. Martinucci, C. Monciotti, A. Ogana, P. Picco, M. Scattoni, L. Spallino, R. Vanini, L. Stocchero, M. Vanelli, G. Chiari, A. Visentin

Research output: Contribution to journalArticlepeer-review


We describe 54 transient focal neurologic deficits (TFND) episodes in 44 children under 18 y observed retrospectively during a 5-y period (1991-96). Mean age and duration of insulin-dependent diabetes mellitus (IDDM) were 8.4 and 3.4 y, respectively. None of the children had a history of seizure disorder and only one had a personal history of migraine. Twenty-nine episodes were characterized by right- and 25 by left-sided hemiparesis. Three of six patients who presented more than one event had alternate episodes of right- and left-sided hemiparesis. On 8 occasions the episode was preceded by a brief convulsion, in 39 it was not witnessed, and in 7 it was certainly absent. Hypoglycaemia (≤2.77 mmol/l) was documented on 26 occasions. On 18 of these 26 occasions, the episodes did not resolve promptly after sugar administration. The clinical course was benign, all patients remained neurologically normal and none developed migraine at follow up. Episodes of TFND were associated with hypoglycaemia in the majority of our cases and we do not consider invasive investigations to be mandatory, since the long-term prognosis was invariably good.

Original languageEnglish
Pages (from-to)542-544
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Issue number5
Publication statusPublished - 1998


  • Children
  • Hemiparesis
  • Hypoglycaemia
  • Insulin-dependent diabetes mellitus
  • Transient focal neurological deficits

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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