TY - JOUR
T1 - Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver
AU - Elli, L.
AU - Bergamini, C. M.
AU - Bardella, M. T.
AU - Schuppan, D.
PY - 2009/8
Y1 - 2009/8
N2 - Transglutaminases are a family of eight currently known calcium-dependent enzymes that catalyze the cross-linking or deamidation of proteins. They are involved in important biological processes such as wound healing, tissue repair, fibrogenesis, apoptosis, inflammation and cell-cycle control. Therefore, they play important roles in the pathomechanisms of autoimmune, inflammatory and degenerative diseases, many of which affect the gastrointestinal system. Transglutaminase 2 is prominent, since it is central to the pathogenesis of celiac disease, and modulates inflammation and fibrosis in inflammatory bowel and chronic liver diseases. This review highlights our present understanding of transglutaminase function in gastrointestinal and liver diseases and therapeutic strategies that target transglutaminase activities.
AB - Transglutaminases are a family of eight currently known calcium-dependent enzymes that catalyze the cross-linking or deamidation of proteins. They are involved in important biological processes such as wound healing, tissue repair, fibrogenesis, apoptosis, inflammation and cell-cycle control. Therefore, they play important roles in the pathomechanisms of autoimmune, inflammatory and degenerative diseases, many of which affect the gastrointestinal system. Transglutaminase 2 is prominent, since it is central to the pathogenesis of celiac disease, and modulates inflammation and fibrosis in inflammatory bowel and chronic liver diseases. This review highlights our present understanding of transglutaminase function in gastrointestinal and liver diseases and therapeutic strategies that target transglutaminase activities.
KW - Celiac disease
KW - Collagen
KW - Crohn's disease
KW - Extracellular matrix
KW - Gliadin
KW - Inflammatory bowel disease
KW - NFkB
KW - Ulcerative colitis
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UR - http://www.scopus.com/inward/citedby.url?scp=65249178698&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2008.12.095
DO - 10.1016/j.dld.2008.12.095
M3 - Article
C2 - 19195940
AN - SCOPUS:65249178698
SN - 1590-8658
VL - 41
SP - 541
EP - 550
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 8
ER -