Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome

André Diedrich, Vasile Urechie, Dana Shiffer, Stefano Rigo, Maura Minonzio, Beatrice Cairo, Emily C Smith, Luis E Okamoto, Franca Barbic, Andrea Bisoglio, Alberto Porta, Italo Biaggioni, Raffaello Furlan

Research output: Contribution to journalArticlepeer-review


Postural Tachycardia Syndrome (POTS) is a chronic disorder characterized by symptoms of orthostatic intolerance such as fatigue, lightheadedness, dizziness, palpitations, dyspnea, chest discomfort and remarkable tachycardia upon standing. Non-invasive transdermal vagal stimulators have been applied for the treatment of epilepsy, anxiety, depression, headache, and chronic pain syndromes. Anti-inflammatory and immunomodulating effects after transdermal vagal stimulation raised interest for applications in other diseases. Patients with sympathetic overactivity, reduced cardiac vagal drive and presence of systemic inflammation like POTS may benefit from tVNS. This article will address crucial methodological aspects of tVNS and provide preliminary results of its acute and chronic use in POTS, with regards to its potential effectiveness on autonomic symptoms reduction and heart rate modulation.

Original languageEnglish
Pages (from-to)102886
JournalAutonomic Neuroscience: Basic and Clinical
Publication statusPublished - Dec 2021


  • Fatigue Syndrome, Chronic
  • Heart Rate
  • Humans
  • Orthostatic Intolerance
  • Postural Orthostatic Tachycardia Syndrome/therapy
  • Tachycardia


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