Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome

André Diedrich; Vasile Urechie; Dana Shiffer; Stefano Rigo; Maura Minonzio; Beatrice Cairo; Emily C Smith; Luis E Okamoto; Franca Barbic; Andrea Bisoglio; Alberto Porta; Italo Biaggioni; Raffaello Furlan

doi:10.1016/j.autneu.2021.102886

Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome

André Diedrich, Vasile Urechie, Dana Shiffer, Stefano Rigo, Maura Minonzio, Beatrice Cairo, Emily C Smith, Luis E Okamoto, Franca Barbic, Andrea Bisoglio, Alberto Porta, Italo Biaggioni, Raffaello Furlan

Research output: Contribution to journal › Article › peer-review

Abstract

Postural Tachycardia Syndrome (POTS) is a chronic disorder characterized by symptoms of orthostatic intolerance such as fatigue, lightheadedness, dizziness, palpitations, dyspnea, chest discomfort and remarkable tachycardia upon standing. Non-invasive transdermal vagal stimulators have been applied for the treatment of epilepsy, anxiety, depression, headache, and chronic pain syndromes. Anti-inflammatory and immunomodulating effects after transdermal vagal stimulation raised interest for applications in other diseases. Patients with sympathetic overactivity, reduced cardiac vagal drive and presence of systemic inflammation like POTS may benefit from tVNS. This article will address crucial methodological aspects of tVNS and provide preliminary results of its acute and chronic use in POTS, with regards to its potential effectiveness on autonomic symptoms reduction and heart rate modulation.

Original language	English
Pages (from-to)	102886
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	236
DOIs	https://doi.org/10.1016/j.autneu.2021.102886
Publication status	Published - Dec 2021

Keywords

Fatigue Syndrome, Chronic
Heart Rate
Humans
Orthostatic Intolerance
Postural Orthostatic Tachycardia Syndrome/therapy
Tachycardia

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10.1016/j.autneu.2021.102886

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Diedrich, A., Urechie, V., Shiffer, D., Rigo, S., Minonzio, M., Cairo, B., Smith, E. C., Okamoto, L. E., Barbic, F., Bisoglio, A., Porta, A., Biaggioni, I., & Furlan, R. (2021). Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome. Autonomic Neuroscience: Basic and Clinical, 236, 102886. https://doi.org/10.1016/j.autneu.2021.102886

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abstract = "Postural Tachycardia Syndrome (POTS) is a chronic disorder characterized by symptoms of orthostatic intolerance such as fatigue, lightheadedness, dizziness, palpitations, dyspnea, chest discomfort and remarkable tachycardia upon standing. Non-invasive transdermal vagal stimulators have been applied for the treatment of epilepsy, anxiety, depression, headache, and chronic pain syndromes. Anti-inflammatory and immunomodulating effects after transdermal vagal stimulation raised interest for applications in other diseases. Patients with sympathetic overactivity, reduced cardiac vagal drive and presence of systemic inflammation like POTS may benefit from tVNS. This article will address crucial methodological aspects of tVNS and provide preliminary results of its acute and chronic use in POTS, with regards to its potential effectiveness on autonomic symptoms reduction and heart rate modulation.",

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AU - Diedrich, André

AU - Urechie, Vasile

AU - Shiffer, Dana

AU - Rigo, Stefano

AU - Minonzio, Maura

AU - Cairo, Beatrice

AU - Smith, Emily C

AU - Okamoto, Luis E

AU - Barbic, Franca

AU - Bisoglio, Andrea

AU - Porta, Alberto

AU - Biaggioni, Italo

AU - Furlan, Raffaello

PY - 2021/12

Y1 - 2021/12

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AB - Postural Tachycardia Syndrome (POTS) is a chronic disorder characterized by symptoms of orthostatic intolerance such as fatigue, lightheadedness, dizziness, palpitations, dyspnea, chest discomfort and remarkable tachycardia upon standing. Non-invasive transdermal vagal stimulators have been applied for the treatment of epilepsy, anxiety, depression, headache, and chronic pain syndromes. Anti-inflammatory and immunomodulating effects after transdermal vagal stimulation raised interest for applications in other diseases. Patients with sympathetic overactivity, reduced cardiac vagal drive and presence of systemic inflammation like POTS may benefit from tVNS. This article will address crucial methodological aspects of tVNS and provide preliminary results of its acute and chronic use in POTS, with regards to its potential effectiveness on autonomic symptoms reduction and heart rate modulation.

KW - Fatigue Syndrome, Chronic

KW - Heart Rate

KW - Humans

KW - Orthostatic Intolerance

KW - Postural Orthostatic Tachycardia Syndrome/therapy

KW - Tachycardia

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DO - 10.1016/j.autneu.2021.102886

M3 - Article

C2 - 34634682

SN - 1566-0702

VL - 236

SP - 102886

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

ER -

Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome

Abstract

Keywords

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