Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes

F. Licastro; C. Franceschi; L. Barbieri; F. Stirpe

doi:10.1007/BF02899186

Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes

F. Licastro, C. Franceschi, L. Barbieri, F. Stirpe

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

A haemagglutinin (lectin) and another protein (inhibitor) purified from the seeds of Momordica charantia inhibited protein and subsequently DNA synthesis in normal (mitogen-stimulated) and leukaemic human peripheral blood lymphocytes. The effect of the lectin was more rapid and more pronounced than that of the inhibitor, probably due to a better penetration of the lectin into cells. Both proteins acted on lymphocytes more markedly and at concentrations much lower than those required to inhibit protein synthesis in Yoshida ascites cells (Barbieri et al., 1980b).

Original language	English
Pages (from-to)	257-265
Number of pages	9
Journal	Virchows Archiv B Cell Pathology Including Molecular Pathology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1007/BF02899186
Publication status	Published - Dec 1980

Keywords

Inhibition of DNA synthesis
Inhibition of protein synthesis
Lymphocytes
Momordica charantia inhibitor
Momordica charantia lectin

ASJC Scopus subject areas

Pathology and Forensic Medicine
Medicine(all)

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10.1007/BF02899186

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abstract = "A haemagglutinin (lectin) and another protein (inhibitor) purified from the seeds of Momordica charantia inhibited protein and subsequently DNA synthesis in normal (mitogen-stimulated) and leukaemic human peripheral blood lymphocytes. The effect of the lectin was more rapid and more pronounced than that of the inhibitor, probably due to a better penetration of the lectin into cells. Both proteins acted on lymphocytes more markedly and at concentrations much lower than those required to inhibit protein synthesis in Yoshida ascites cells (Barbieri et al., 1980b).",

keywords = "Inhibition of DNA synthesis, Inhibition of protein synthesis, Lymphocytes, Momordica charantia inhibitor, Momordica charantia lectin",

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AU - Licastro, F.

AU - Franceschi, C.

AU - Barbieri, L.

AU - Stirpe, F.

PY - 1980/12

Y1 - 1980/12

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AB - A haemagglutinin (lectin) and another protein (inhibitor) purified from the seeds of Momordica charantia inhibited protein and subsequently DNA synthesis in normal (mitogen-stimulated) and leukaemic human peripheral blood lymphocytes. The effect of the lectin was more rapid and more pronounced than that of the inhibitor, probably due to a better penetration of the lectin into cells. Both proteins acted on lymphocytes more markedly and at concentrations much lower than those required to inhibit protein synthesis in Yoshida ascites cells (Barbieri et al., 1980b).

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KW - Inhibition of protein synthesis

KW - Lymphocytes

KW - Momordica charantia inhibitor

KW - Momordica charantia lectin

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Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes

Abstract

Keywords

ASJC Scopus subject areas

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