Torulopsis glabrata Vaginitis

Arsenio Spinillo, Ezio Capuzzo, Thomas O. Egbe, Federica Baltaro, Sabrina Nicola, Gaia Piazzi

Research output: Contribution to journalArticlepeer-review


Objective: To study the sociodemographic risk factors and clinical features of Torulopsis glabrata vaginal infection,. Methods: We evaluated the sociodemographic and clinical characteristics of 86 consecutive symptomatic women attending a vaginitis clinic and isolated T glabrata. Case patients were compared with a control group of 174 asymptomatic women with negative vaginal cultures and an additional group of 625 symptomatic women with vaginal cultures positive for Candida albicans. In addition, the sensitivity of the isolates to the more common antimycotic agents used was tested by the modified Kirby-Bauer method. Results: Patients with T glabrata vaginal infection were from lower socioeconomic backgrounds and had less education. They were more likely to use vaginal tampons and to be seropositive for human immunodeficiency virus than were negative controls. Compared with C albicans infection, T glabrata was more frequent among women over 38 years of age and in those with less education and of lower social class. In logistic regression analysis, T glabrata was associated more frequently with recurrent vaginal candidiasis than was C albicans (odds ratio 2.46, 95% confidence interval 1.33-4.54; P = .004). Six of the 86 (7%) T glabrata isolates and none of the C albicans isolates (P <.001 by Fisher exact test) were resistant to the imidazole derivatives tested. Conclusion: Torulopsis glabrata was isolated in 10% of women with vulvovaginal candidiasis attending a vaginitis clinic. This infection was associated with recurrent vaginitis in almost one-third of case patients presenting with symptoms.

Original languageEnglish
Pages (from-to)993-998
Number of pages6
JournalObstetrics and Gynecology
Issue number6
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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