Topiramate in migraine prophylaxis

D. D'Amico; L. Grazzi; S. Usai; F. Moschiano; G. Bussone

doi:10.1007/s10072-005-0425-6

Topiramate in migraine prophylaxis

D. D'Amico, L. Grazzi, S. Usai, F. Moschiano, G. Bussone

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

This paper reviews results of placebo-controlled trials on topiramate (TPM) prophylaxis in migraine patients, and discusses issues regarding the use of this medication in clinical practice. Data from well conducted double-blind controlled trials and from a comparative trial show that TPM is effective against migraine, confirming the experience of physicians in various countries. Lack of major contraindications, high responder rate, good tolerability at the target dose (100 mg/day) following slow titration, and lack of weight gain make TPM one of the most effective and well accepted drugs for migraine prophylaxis.

Original language	English
Journal	Neurological Sciences
Volume	26
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1007/s10072-005-0425-6
Publication status	Published - May 2005

Keywords

Clinical practice
Clinical trial
Migraine
Prophylaxis
Topiramate

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

Access to Document

10.1007/s10072-005-0425-6

Cite this

@article{5130ea2d96b6492ab58893b98dffe1de,

title = "Topiramate in migraine prophylaxis",

abstract = "This paper reviews results of placebo-controlled trials on topiramate (TPM) prophylaxis in migraine patients, and discusses issues regarding the use of this medication in clinical practice. Data from well conducted double-blind controlled trials and from a comparative trial show that TPM is effective against migraine, confirming the experience of physicians in various countries. Lack of major contraindications, high responder rate, good tolerability at the target dose (100 mg/day) following slow titration, and lack of weight gain make TPM one of the most effective and well accepted drugs for migraine prophylaxis.",

keywords = "Clinical practice, Clinical trial, Migraine, Prophylaxis, Topiramate",

author = "D. D'Amico and L. Grazzi and S. Usai and F. Moschiano and G. Bussone",

year = "2005",

month = may,

doi = "10.1007/s10072-005-0425-6",

language = "English",

volume = "26",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia s.r.l.",

number = "SUPPL. 2",

}

TY - JOUR

T1 - Topiramate in migraine prophylaxis

AU - D'Amico, D.

AU - Grazzi, L.

AU - Usai, S.

AU - Moschiano, F.

AU - Bussone, G.

PY - 2005/5

Y1 - 2005/5

N2 - This paper reviews results of placebo-controlled trials on topiramate (TPM) prophylaxis in migraine patients, and discusses issues regarding the use of this medication in clinical practice. Data from well conducted double-blind controlled trials and from a comparative trial show that TPM is effective against migraine, confirming the experience of physicians in various countries. Lack of major contraindications, high responder rate, good tolerability at the target dose (100 mg/day) following slow titration, and lack of weight gain make TPM one of the most effective and well accepted drugs for migraine prophylaxis.

AB - This paper reviews results of placebo-controlled trials on topiramate (TPM) prophylaxis in migraine patients, and discusses issues regarding the use of this medication in clinical practice. Data from well conducted double-blind controlled trials and from a comparative trial show that TPM is effective against migraine, confirming the experience of physicians in various countries. Lack of major contraindications, high responder rate, good tolerability at the target dose (100 mg/day) following slow titration, and lack of weight gain make TPM one of the most effective and well accepted drugs for migraine prophylaxis.

KW - Clinical practice

KW - Clinical trial

KW - Migraine

KW - Prophylaxis

KW - Topiramate

UR - http://www.scopus.com/inward/record.url?scp=20444383872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444383872&partnerID=8YFLogxK

U2 - 10.1007/s10072-005-0425-6

DO - 10.1007/s10072-005-0425-6

M3 - Article

C2 - 15926010

AN - SCOPUS:20444383872

SN - 1590-1874

VL - 26

JO - Neurological Sciences

JF - Neurological Sciences

IS - SUPPL. 2

ER -

Topiramate in migraine prophylaxis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this