Topical corticosteroids b.i.d. are commonly used in the treatment of contact dermatitis. This study evaluates the efficacy of a new corticosteroid molecule designed for s.i.d. use. 9 healthy subjects entered the study on the volar foream, a random selection of 4 areas, 4 cm 2 each was made. One site served as control. Irritation was induced by occlusive application of 5% sodium lauryl sulphate in water on the other 3 sites. The irritated sites were treated for 4 days respectively with: 0.025% budesonide in cream (b.i.d.), methylprednisolone aceponate 0.1% in cream (s.i.d.) and base cream (s.i.d.). Recovery of irritation was monitored by transepidermal water loss (TEWL) measurements. The results show significant differences between the treatments at the 3rd (p <0.03) and 4th (p <0.05) day. The data show a marked reduction in TEWL values in the site treated with the molecule designed for a once a day application. In conclusion, the study demonstrates that methylprednisolone aceponate 0.1% is effective in treating skin irritation. The use of these corticosteroids may increase the patient's compliance and reduce the risk of side effects.
|Translated title of the contribution||Topical corticosteroids in the treatment of irritant dermatitis: s.i.d. or b.i.d.?|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1994|
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